Penta-1,3-diene

Endpoint summary

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion

Additional information:

Penta-1,3-dieneis a flammable (Flam. Liq. 2) liquid substance.

Evaluation of available QSAR models and using the SAR approach does not provide evidence supporting sensitizing activity ofpenta-1,3-diene.

In addition, no human data associated with allergy topenta-1,3-dienewere reported.

In conclusion, based on the skin sensitization data summarized here and taking into account that there have been no reports of skin sensitization caused bypenta-1,3-diene, it is not considered to be a skin sensitizer.

Respiratory sensitisation

Endpoint conclusion

Additional information:

In accordance with the CLP criteria, respiratory sensitizer is defined as “a substance that will lead to hypersensitivity of the airways following inhalation of the substance”. Generally, a substance is classified as respiratory sensitizer if there is evidence in humans that the substance can lead to specific respiratory hypersensitivity and/or if there are positive results from an appropriate animal test.

Currently, no recognized animal models for the testing of respiratory hypersensitivity are available.

Therefore, evidence that a substance can induce specific respiratory hypersensitivity will normally be based on human experience. However, no hypersensitivity reactions associated with exposure topenta-1,3-dienewere reported in humans.

In conclusion, based on the respiratory sensitization data summarized here and taking into account that there have been no reports of respiratory sensitization caused bypenta-1,3-diene, it is not considered to be a respiratory sensitizer.