Registration Dossier
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EC number: 225-714-1 | CAS number: 5026-62-0
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
LC50 (96 h) = 59.5 mg/L for Oryzias latipes (OECD 203), read across
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 59.5 mg/L
Additional information
No studies investigating the short-term toxicity of sodium methylparaben (CAS No. 5026-62-0) to fish are available. Therefore, toxicity data of the corresponding acid methylparaben (CAS No. 99-76-3) are used as read across.
This read across approach is in accordance with Regulation (EC) No 1907/2006, Annex XI, 1.5. Grouping of substance and read across approach as is explained within the analogue justification in section 13. Except for different cations (hydrogen vs. sodium) the anions of both the source and target substance have identical chemical structures. Since dissociation of the sodium salt under environmental conditions (pH 4 - 9) yields the same ionic species as the acidic form of the substance, this read across can be considered as justified.
For the short-term toxicity of the analogue read across substance methylparaben towards fish one study is available (Anon., 2000) and the results are published by the Ministry of the Environment of Japan. Rice fish (Oryzias latipes) was exposed under semi-static conditions according to OECD guideline 203 and GLP. Analytics of the test substance in the test media showed measured concentrations to be≥80% of nominal values. An LC50 (96 h) of 59.5 mg/L (nominal) is reported. This value was used for assessment.
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