Registration Dossier
Registration Dossier
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EC number: 255-464-9 | CAS number: 41621-49-2
Partition coefficient
Administrative data
- Endpoint:
- partition coefficient
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 016
- Report date:
- 2016
Materials and methods
- Principles of method if other than guideline:
- About 1 mg of sample was dissolved in a biphasic system of water and 1-octanol. The two phases were separated and UV-visible spectra of each phase were recorded by UV/vis spectrometer.
- GLP compliance:
- no
- Type of method:
- other: dissolution in water-octanol system and absorbance measurement of the two phases
- Partition coefficient type:
- octanol-water
Test material
- Reference substance name:
- 6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
- EC Number:
- 255-464-9
- EC Name:
- 6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
- Cas Number:
- 41621-49-2
- Molecular formula:
- C12H17NO2.C2H7NO
- IUPAC Name:
- 6-cyclohexyl-1-hydroxy-4-methylpyridin-2(1H)-one, compound with 2-aminoethanol (1:1)
- Test material form:
- solid: particulate/powder
Constituent 1
Results and discussion
Partition coefficient
- Type:
- log Pow
- Partition coefficient:
- 0.52
- Remarks on result:
- other: Temperature and pH not available
Any other information on results incl. tables
ABS 1-octanol = 4.1730
ABS water = 1.2669
Log Pow= Log (ABS 1-octanol / ABS water)
Applicant's summary and conclusion
- Conclusions:
- LogPow of the Ciclopirox olamine is 0.52.
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