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Diss Factsheets
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EC number: 285-480-1 | CAS number: 85099-25-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- key study
- Reason / purpose for cross-reference:
- read-across source
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- > 2 680 mg/kg diet
- Based on:
- other: calculated for target substance to be registered
- Sex:
- male/female
- Basis for effect level:
- other: NOAEL = highest dose tested
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- > 160 mg/kg bw/day (actual dose received)
- Based on:
- other: calculated for target substance to be registered
- Sex:
- male/female
- Basis for effect level:
- other: NOAEL = highest dose tested
- Key result
- Critical effects observed:
- no
Reference
Calculation of the NOAEL for the read-across target substance, i.e. the phosphate salt of cyclohexyldimethylamine, from the result obtained in the OECD 422 study performed with the read-across source substance cyclohexyldimethylamine.
In the OECD 422 study the NOAEL was derived at the level of 1500 ppm cyclohexyldimethylamine in the diet; this was the highest dose tested due to palatability issues. This dietary concentration corresponded to dose levels of 91 – 104 mg/kg body weight/day for males and to 85 – 147 mg/kg body weight/day for females. This is summarised to a NOAEL of cyclohexyldimethylamine of > 90 mg/kg body weight/day for males and females.
This NOAEL is converted to the NOAEL of the read-across target substance, i.e. the phosphate salt of cyclohexyldimethylamine, by multiplication with the factor 1.786 resulting in 2680 ppm in diet and 160 mg/kg body weight/day.
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: inhalation - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - systemic effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Repeated dose toxicity: dermal - local effects
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for classification or non-classification
In the repeated dose oral toxicity study performed with the read-across source substance no effects were observed up to and including the highest dose of 1500 ppm in the diet. This dose level of the r-a source substance corresponds to a dose level of the target substance to be registered of > 160 mg/kg body weight/day for males and females. In the absence of any adverse effects non-classification is justified.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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