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EC number: 291-905-1 | CAS number: 90506-43-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
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Short-term toxicity to aquatic invertebrates
Administrative data
Link to relevant study record(s)
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Remarks:
- Data are included only to justify the read-across approach of the dossier
- Adequacy of study:
- key study
- Study period:
- 2012-02-14 to 2012-02-17
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- Qualifier:
- according to guideline
- Guideline:
- EU Method C.2 (Acute Toxicity for Daphnia)
- GLP compliance:
- yes (incl. QA statement)
- Specific details on test material used for the study:
- Silastol H 200 TS
- Analytical monitoring:
- yes
- Vehicle:
- no
- Details on test solutions:
- As solubility lies below 100 mg/L, the water-accommodated fraction was prepared for the test. This was done by weigh ing the nominal load,
adding the corresponding amount of dilution water and shaking vigorously for 24 hours. The resulting solution was unfiltrated used as test solution. - Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna / STRAUS
- Strain: Berlin
- Source: Umweltbundesamt Berlin/ Daphnia magna is bred in the LAUS GmbH throughout the year
- Age at study initiation (mean and range, SD): 0 - 24 hours
- Weight at study initiation (mean and range, SD): no data
- Length at study initiation (length definition, mean, range and SD): no data
- Valve height at study initiation, for shell deposition study (mean and range, SD): no data
- Peripheral shell growth removed prior to test initiation: no data
- Method of breeding: Daphnia magna is bred in the LAUS GmbH throughout the year. The husbandry is performed similar to the method described in EN ISO 6341
- Feeding during test none
ACCLIMATION
- Acclimation conditions (same as test or not): no data
- Type and amount of food: unicellular green algae (Desmodesmus subspicatus)
- Feeding frequency: twice a week - Test type:
- static
- Water media type:
- freshwater
- Limit test:
- yes
- Total exposure duration:
- 48 h
- Hardness:
- 2.502 mmol/L
- Test temperature:
- Temperature range was 18.0 - 19.7°C.
- pH:
The pH values in the test media and the control ranged from 7.6 to 7.7.- Dissolved oxygen:
- The concentration of dissolved oxygen stayed above 9.4 mg/L throughout the test.
- Nominal and measured concentrations:
- 100 mg/L nominal
- Details on test conditions:
- TEST SYSTEM
- Test vessel: glass beakers, nominal volume 50 mL, tall shape
- Material, size, headspace, fill volume: 50 mL
- Aeration: no
- Renewal rate of test solution (frequency/flow rate):
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
TEST MEDIUM / WATER PARAMETERS no data
OTHER TEST CONDITIONS
- Adjustment of pH: After preparation, the dilution water is aerated, and the pH is adjusted to 7.8 ± 0.2.
- Photoperiod: non
EFFECT PARAMETERS MEASURED (with observation intervals if applicable) :
The immobilised daphnia were counted. Daphnia are considered immobilised if they perform no movements or are only able to move their antennae
when the beaker is gently agitated. Daphnia which are trapped at the surface of the test solution are also considered immobilised. - Reference substance (positive control):
- yes
- Remarks:
- Potass ium dichromate K2Cr207 (CAS No. 7778-50-9)
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC50
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: water-accommodated fraction (WAF)
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- NOEC
- Effect conc.:
- >= 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- other: water-accommodated fraction (WAF)
- Basis for effect:
- mobility
- Details on results:
- None of the daphnia died or showed any signs of abnormal behaviour throughout the test.
- Results with reference substance (positive control):
- NOEC 24 h = 0.625 mg/L
24h EC50 = 1.7 mg/L (1.2 - 2.5 mg/L)
24h EC100 = 3 mg/L - Validity criteria fulfilled:
- yes
- Conclusions:
- The EC50 was determined to be > 100 mg/L Silastol H 200 TS (WAF based on nominal concentration).
The NOEC was determined to be ≥ 100 mg/L Silastol H 200 TS (WAF based on nominal concentration). - Executive summary:
All validity criteria were met. For the estimation of the EC50 of the positive control, the fit showed sufficient statistical corre spondence of the data with the dose-response-equation. The 24h -EC50 of potassium dichromate was determined as 1.7 mg/L, lying within the demanded range of 0.6 - 1.7 mg/L. In the main study, the treatment showed no toxicity. None of the animals were immobilised in the control.
Because of the poor solubility in water, the analytical determin ation s of the test item showed weak correlation between nominal and measured concentration s. The measured DOC values in the test solution and in the control were below the limit of quantification. Therefore, the determination of the results was based on the nomin al concentrations. The result of the test can be considered valid.
None of the daphnia died or showed any signs of abnormal behaviour throughout the test.
- Endpoint:
- short-term toxicity to aquatic invertebrates
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2016-10-10 to 2017-02-06
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- guideline study without detailed documentation
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
- GLP compliance:
- no
- Remarks:
- laboratory is accredited for this test method according to ISO 17025
- Vehicle:
- no
- Test organisms (species):
- Daphnia magna
- Details on test organisms:
- TEST ORGANISM
- Common name: Daphnia magna
- Strain/clone: STRAUS
- Source: Umweltbundesamt Berlin
- Age of parental stock (mean and range, SD): no information
- Feeding during test: no
ACCLIMATION
- Acclimation period:
- Acclimation conditions (same as test or not):
- Type and amount of food: green algae
- Feeding frequency: daily
- Health during acclimation (any mortality observed):
- Test type:
- static
- Water media type:
- freshwater
- Limit test:
- no
- Total exposure duration:
- 48 h
- Test temperature:
- 18-22 °C
- pH:
- 7.4
- Nominal and measured concentrations:
- nominal concnetrations:
Test 1: 1.0, 2.0, 4.0, 7.0, 10, 22, 48, 100, 200 mg/L - Details on test conditions:
- TEST SYSTEM
- Test vessel: test tube
- Aeration: no
- No. of organisms per vessel: 5
- No. of vessels per concentration (replicates): 4
- No. of vessels per control (replicates): 4
OTHER TEST CONDITIONS
- Adjustment of pH: no
- Photoperiod: 16:8
- Light intensity: 500 - 600 Lux
VEHICLE CONTROL PERFORMED: no
- Reference substance (positive control):
- yes
- Remarks:
- Test performed on 2017-01-10
- Key result
- Duration:
- 24 h
- Dose descriptor:
- EC0
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Key result
- Duration:
- 48 h
- Dose descriptor:
- EC0
- Effect conc.:
- > 100 mg/L
- Nominal / measured:
- nominal
- Conc. based on:
- test mat.
- Basis for effect:
- mobility
- Results with reference substance (positive control):
- - Results with reference substance valid:
yes
- Relevant effect levels: EC50 (24h): 1.81 mg/L - Validity criteria fulfilled:
- yes
- Conclusions:
- The 48-hour EC50 of Phosphoric acid, C12-18 alkyl esters, potassium salts was > 200 mg/L (nominal).
- Executive summary:
The 48-hr-acute toxicity of Phosphoric acid, C12-18 alkyl esters, potassium salts to Daphnia magna was studied under static conditions according to OECD Guideline 202. Daphnids were exposed to control and test chemical at nominal concentrations of 1.0, 2.0, 4.0, 7.0, 10, 22, 48, 100, 200 mg/L a.i./L in fresh water for 48 h.
The 48-hour EC50 was > 200 mg/L nominal
This study is classified as acceptable and satisfies the guideline requirements for an acute toxicity study with freshwater invertebrates.
Results Synopsis
Test Organism Age: max. 24 h old daphnids
Test Type: Static
48h-EC50: > 200 mg/L nominal
Endpoint(s) Effected: mobility
Referenceopen allclose all
Description of key information
The 48-hour EC50 of 100 mg/L was used for chemical safety assessment of Phosphoric acid, C12-18 alkyl esters, potassium salts.
Key value for chemical safety assessment
Fresh water invertebrates
Fresh water invertebrates
- Effect concentration:
- 100 mg/L
Additional information
The 48-hr-acute toxicity of Phosphoric acid, C12-18 alkyl esters, potassium salts to Daphnia magna was studied under static conditions according to OECD Guideline 202.
Daphnids were exposed to control and test chemical at nominal concentrations of 1.0, 2.0, 4.0, 7.0, 10, 22, 48, 100, 200 mg/L a.i./L in fresh water for 48 h.
The 48-hour EC50 was > 200 mg/L nominal (based on mobility).
Similar results were obtained with the read-across substance 1-Octadecanol, phosphate, potassium salt. In a study concocted according to OECD guideline 202, the 48h-EC50 was determined to be > 100 mg/L
(WAF based on nominal concentration). The NOEC was determined to be ≥ 100 mg/L (WAF based on nominal concentration).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
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