Registration Dossier
Registration Dossier
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EC number: 500-707-9 | CAS number: 162353-70-0
Toxicity to aquatic algae and cyanobacteria
Administrative data
Link to relevant study record(s)
Description of key information
No toxic effects on aquatic algae up to the limit of water solubility, read across.
Key value for chemical safety assessment
Additional information
Data on the toxicity of the target substance Fatty acids, C18-unsatd., dimers, reaction products with fatty acids, C14-18 and C16-18-unsatd. and propylidynemethanol (CAS 162353-70-0) to aquatic algae are not available. The assessment was therefore based on studies conducted with the analogue substances C18 Fatty acid, dimers, mixed ester with oleic acid and trimethylolpropane (CAS 147256-33-5) and Fatty acids, C16-18 and C18-unsatd., triesters with trimethylolpropane (CAS 68002-78-8) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.1 and within the analogue justification in IUCLID section 13.
The toxicity of Fatty acids, C18-unsatd., dimers, mixed esters with oleic acid and trimethylolpropane (CAS No. 147256-33-5) to freshwater algae was tested according to OECD guideline 201 using Desmodesmus subspicatus as test organism (BMG Engineering Ltd., 2012). The test was set up as a limit test using a water accommodated fraction (WAF) with a loading rate of 100 mg/L as test concentration. No test substance monitoring was performed. Based on the algal growth rate a 72 h-EL50 was determined > 100 mg/L (nominal) was determined. The determined 72 h-NOELR was ≥ 100 mg/L (nominal).
The short-term toxicity of the source substance Fatty acids, C16-18 and C18-unsatd., triesters with trimethylolpropane (CAS 68002-78-8) to aquatic algae was tested in compliance with OECD guideline 201 ( Laboratoire d'Analyses de Fluides, 2012). The study was set up as a limit test. Pseudokirchnerella subcapitata were exposed to the substance for 72 hours. The test solution was prepared by using the water accommodated fraction (WAF) of the test substance (nominal loading rate 0.110 g/1000 g). Based on the growth rate of algae an EL50 > 110 mg/L (nominal) was determined.
Based on the results of the read across substances (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) toxic effects of Fatty acids, C18-unsatd., dimers, reaction products with fatty acids, C14-18 and C16-18-unsatd. and propylidynemethanol to aquatic algae are not expected.
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