Registration Dossier
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EC number: 500-707-9 | CAS number: 162353-70-0
Toxicity to soil macroorganisms except arthropods
Administrative data
Link to relevant study record(s)
Description of key information
NOEC (28 d) ≥ 10000 mg/kg dw for Eisenia fetida (OECD 222); read across
Key value for chemical safety assessment
Additional information
There are no studies available on the toxicity of Fatty acids, C18-unsatd., dimers, reaction products with fatty acids, C14-18 and C16-18-unsatd. and propylidynemethanol to terrestrial macroorganisms. The assessment was therefore based on a study conducted with the analogue substance 2-ethyl-2-(((1-oxoisooctadecyl)oxy)methyl)-1,3-propanediyl bis (isooctadecanoate) (CAS 68541-50-4) as part of a read across approach, which is in accordance with Regulation (EC) No. 1907/2006, Annex XI, 1.5. Further justification is given within the overall summary chapter 6.3 and within the analogue justification in IUCLID section 13.
The toxicity of the source substance of 2-ethyl-2-(((1-oxoisooctadecyl)oxy)methyl)-1,3-propanediyl bis (isooctadecanoate) (CAS 68541-50-4) was tested in a long-term toxicity study according to OECD guideline 222. The effect of the test substance on earthworm survival, growth and reproduction was tested in accordance with GLP provisions (Harlan Laboratories Ltd., 2013). The test was conducted with artificial soil that was mixed with the test substance. Earthworms of the species Eisenia fetida were exposed to the test substance for 28 days and then removed from the test substrate. The survival rate and growth (body weight) of the specimen were determined. After another 28 days the hatched juveniles were collected from the test substrate and the reproduction rate was recorded. Mortality or a decrease in body weight of the adult earthworms was not observed. Thus a NOEC > 1000 mg/kg soil based on mortality was reported. A NOEC ≥ 1000 mg/kg soil based on the reproduction rate was determined.
Based on the results of the read across substance (in accordance to Regulation (EC) No 1907/2006 Annex XI, 1.5) toxic effects of Fatty acids, C18-unsatd., dimers, reaction products with fatty acids, C14-18 and C16-18-unsatd. and propylidynemethanol to terrestrial macroorganism are not anticipated.
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