Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 940-029-4 | CAS number: 1474044-86-4
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 310 µg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 216
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 67 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- According to Guidance on information requirements and chemical safety assessment Chapter R.8. Characterisation of dose [concentration]-response for human health, Section R.8.4.3.1.Tables R.8-3 and R.8-4, pages 30-32.
- Justification:
- NOAEL is used.
- AF for differences in duration of exposure:
- 6
- Justification:
- Subacute to chronic as per According to Guidance on information requirements and chemical safety assessment Chapter R.8. Characterisation of dose [concentration]-response for human health, Section R.8.4.3.1. Table R.8-5, page 35.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- According to Guidance on information requirements and chemical safety assessment Chapter R.8. Characterisation of dose [concentration]-response for human health, Section R.8.4.3.1.Tables R.8-3 and R.8-4, pages 30-32.
- AF for intraspecies differences:
- 3
- Justification:
- According to Guidance on information requirements and chemical safety assessment Chapter R.8. Characterisation of dose [concentration]-response for human health, Section R.8.4.3.1. Appendix R.8-3. Table R.8-19, page76-77.
- AF for the quality of the whole database:
- 3
- Justification:
- Lack of long-term repeated dose 90-day study, reproductive and developmental study data and use of read-across.
Acute/short term exposure
DNEL related information
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
Use of read-across to fill data gaps for the subject of Registration,Neononanoic acid glycidyl ester (2,3 -epoxypropyl neonoanoate) CAS No. 144548 -01-6, from 2,3 -epoxypropyl neodecanoate (EC No. 247-979-2/CAS No. 26761-45-5/REACH Registration: 01-2119431597-33-0000) is justified in the attachment.
General Population - Hazard via inhalation route
Systemic effects
Acute/short term exposure
DNEL related information
Local effects
Acute/short term exposure
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 185 µg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 360
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 67 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- According to Guidance on information requirements and chemical safety assessment Chapter R.8. Characterisation of dose [concentration]-response for human health, Section R.8.4.3.1.Tables R.8-3 and R.8-4, pages 30-32.
- Justification:
- NOAEL was used.
- AF for differences in duration of exposure:
- 6
- Justification:
- Subacute to chronic as per According to Guidance on information requirements and chemical safety assessment Chapter R.8. Characterisation of dose [concentration]-response for human health, Section R.8.4.3.1. Table R.8-5, page 35.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- According to Guidance on information requirements and chemical safety assessment Chapter R.8. Characterisation of dose [concentration]-response for human health, Section R.8.4.3.1.Tables R.8-3 and R.8-4, pages 30-32.
- AF for intraspecies differences:
- 5
- Justification:
- According to Guidance on information requirements and chemical safety assessment Chapter R.8. Characterisation of dose [concentration]-response for human health, Section R.8.4.3.1. Appendix R.8-3. Table R.8-19, page76-77.
- AF for the quality of the whole database:
- 3
- Justification:
- Lack of long-term repeated dose 90-day study, reproductive and developmental study data and use of read-across.
Acute/short term exposure
DNEL related information
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 185 µg/kg bw/day
- Most sensitive endpoint:
- repeated dose toxicity
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- ECHA REACH Guidance
- Overall assessment factor (AF):
- 360
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 67 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
- According to Guidance on information requirements and chemical safety assessment Chapter R.8. Characterisation of dose [concentration]-response for human health, Section R.8.4.3.1.Tables R.8-3 and R.8-4, pages 30-32.
- Justification:
- NOAEL was used.
- AF for differences in duration of exposure:
- 6
- Justification:
- Subacute to chronic as per According to Guidance on information requirements and chemical safety assessment Chapter R.8. Characterisation of dose [concentration]-response for human health, Section R.8.4.3.1. Table R.8-5, page 35.
- AF for interspecies differences (allometric scaling):
- 4
- Justification:
- According to Guidance on information requirements and chemical safety assessment Chapter R.8. Characterisation of dose [concentration]-response for human health, Section R.8.4.3.1.Tables R.8-3 and R.8-4, pages 30-32.
- AF for intraspecies differences:
- 5
- Justification:
- According to Guidance on information requirements and chemical safety assessment Chapter R.8. Characterisation of dose [concentration]-response for human health, Section R.8.4.3.1. Appendix R.8-3. Table R.8-19, page76-77.
- AF for the quality of the whole database:
- 3
- Justification:
- Lack of long-term repeated dose 90-day study, reproductive and developmental study data and use of read-across.
Acute/short term exposure
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Use of read-across to fill data gaps for the subject of Registration,Neononanoic acid glycidyl ester (2,3 -epoxypropyl neonoanoate) CAS No. 144548 -01-6, from 2,3 -epoxypropyl neodecanoate (EC No. 247-979-2/CAS No. 26761-45-5/REACH Registration: 01-2119431597-33-0000) is justified in the attachment.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
