Reaction mass of (2S)-2-[(4R)-2-oxo-4-propylpyrrolidin-1-yl]butanamide and (2S)-2-[(4S)-2-oxo-4-propylpyrrolidin-1-yl]butanamide

Surface tension

Link to relevant study record(s)

Reference

Endpoint:

surface tension

Type of information:

experimental study

Adequacy of study:

key study

Study period:

12 September 2006 - 6 October 2006

Reliability:

1 (reliable without restriction)

Rationale for reliability incl. deficiencies:

guideline study

Qualifier:

according to guideline

Guideline:

EU Method A.5 (Surface Tension)

Deviations:

yes

Remarks:

see below

Qualifier:

equivalent or similar to guideline

Guideline:

other: ISO 304 ring method

Deviations:

no

Principles of method if other than guideline:

Deviation: The surface tension result was not corrected using the Harkins-Jordan correction table as the correction is not applicable to the apparatus used. Once calibrated, the balance and ring assembly used in this test give a direct reading for surface tension that is within the required accuracy (± 0.5 mN/m); this is as a result of the reduced ring dimensions. This deviation has been considered not to have affected the integrity of the study.

GLP compliance:

yes (incl. QA statement)

Type of method:

ring method

Surface tension:

63 mN/m

Temp.:

22.4 °C

Conc.:

1 g/L

Conclusions:

The surface tension of a 1.00 g/L solution of test substance has been determined to be 63.0 mN/m at 22.4 ± 0.5°C. The test substance is considered not to be a surface-active material.

Description of key information

The surface tension of a 1.00 g/L solution of test substance has been determined to be 63.0 mN/m at 22.4 ± 0.5°C. The test substance is considered not to be a surface-active material.

Key value for chemical safety assessment

Surface tension:

63

in mN/m at 20°C and concentration in mg/L:

1 000