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EC number: 203-965-8 | CAS number: 112-38-9
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
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- Flash point
- Auto flammability
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- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
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- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
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- Endpoint summary
- Stability
- Biodegradation
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- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
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- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
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- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
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- Additional toxicological data

Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 1999-03-31 till 1999-04-14
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- guideline study
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 999
- Report date:
- 1999
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- according to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- no
- Qualifier:
- according to guideline
- Guideline:
- EU Method B.3 (Acute Toxicity (Dermal))
- Deviations:
- no
- GLP compliance:
- yes
- Test type:
- standard acute method
- Limit test:
- yes
Test material
- Reference substance name:
- Undec-10-enoic acid
- EC Number:
- 203-965-8
- EC Name:
- Undec-10-enoic acid
- Cas Number:
- 112-38-9
- Molecular formula:
- C11H20O2
- IUPAC Name:
- undec-10-enoic acid
- Details on test material:
- - Physical state: Colorless liquid
- Analytical purity: 99.4%
- Stability under test conditions: stable in dark at RT
- batch 9807016 filling 41/99
- expiry data: Jan. 2000
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Sprague-Dawley
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- SD ICO : OFA-SD (IOPS Caw)
TEST ANIMALS
- Source: Iffa Crédo, L`Arbresle, France
- Age at study initiation: 8 weeks
- Weight at study initiation: 251 +/-4 g (males) 227 +/-12g (females)
- Housing: individually during treatment in polycarvbonate cages on dust-free sawdust
- Diet (e.g. ad libitum): ad lib.
- Water (e.g. ad libitum): ad lib.
- Acclimation period: in groups, at least 5 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 21+/-2
- Humidity (%): 30-70
- Air changes (per hr): 12
- Photoperiod (hrs dark / hrs light): 12/12
Administration / exposure
- Type of coverage:
- semiocclusive
- Vehicle:
- unchanged (no vehicle)
- Details on dermal exposure:
- one single administration of unchanged substance on gauze moistened with 2 ml water
- Duration of exposure:
- 24 h
- Doses:
- 2000 mg /kg BW
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- - Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight - Statistics:
- no data
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD0
- Effect level:
- > 2 000 mg/kg bw
- Mortality:
- Animals observed frequently on day of treatment, afterwards once daily, for mortality and clinical signs;
no deaths observed. - Clinical signs:
- other: Animals observed frequently on day of treatment, afterwards once daily, for mortality and clinical signs; no clinical signs and cutaneous reactions observed.
- Gross pathology:
- Necropsy and gross pathology was performed on day 15;
macroscopic examination revealed no apparent abnormalities.
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- Under the experimental conditions, the dermal LD0 of the test substance Undecylenic Acid is equal or higher than 2000 mg/kg in rats. No signs of toxicity were observed at this dose.
- Executive summary:
The acute dermal toxicity of the test substance Undecylenci Acid (named ACIDE UDECYLENIQUE in this report) was evaluated in rats according to OECD No. 402 and EC 92/69/EEC B.3 guidelines. The test substance was applied in its original form at a dose of 2000 mg/kg to the skin of ten Sprague-Dawley rats (five males and five females) for 24 h, and animals were observed for 15 days. Mortality, clinical signs, reduction of body weight gain and abnormalities in gross pathology were not evident.
Under the experimental conditions, the dermal LD0 of the test substance Undecylenic Acid is equal or higher than 2000 mg/kg in rats. No signs of toxicity were observed at this dose.
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