Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 642-362-8 | CAS number: 1190630-03-5
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Additional information
Ziegler Bottoms are characterized as comprising of two primary constituents; icosan-1-ol and docosan-1-ol. Together these constituents represent a structural class of components (alcohols) that constitute approximately 82% of the composition of Ziegler Bottoms. Study data, where available, for each of these primary constituents has been evaluated and considered together. In a conservative approach the most sensitive study result from across the two constituents has been identified and used to address the endpoint in question.
The Key study for each endpoint, which is the most sensitive study result from across the two Ziegler Bottoms constituents, is summarized below. There was no reliable toxicity data for aquatic plants therefore a waiver is applied for that endpoint.
Short-term Toxicity to Fish
The short-term toxicity in fish of components of Ziegler Bottoms has been documented within this dossier. Adequate reliable measured data exists for short-term toxicity to fish to components of Ziegler Bottoms (namely, icosan-1-ol and docosan-1-ol). In a conservative approach the most sensitive study result from across the two constituents has been identified and used to address the hazard endpoint in question. The most sensitive study result from across the two substances has been identified as a reliable study with octadecan-1-ol (Wetton 1996), with read-across applied to icosan-1-ol, which reports an LC50for short term toxicity in fish of >0.0011 mg/L, which is at the limit of solubility. Consequently this value will be taken as the short-term toxicity in fish endpoint for Ziegler Bottoms.
Long-term Toxicity to Fish
In accordance with REACH Annex XI, section 1, testing does not appear scientifically necessary for Annex endpoint 9.1.6. Sufficient information is available to predict an absence of toxicity at the limit of solubility for linear alcohols with carbon chain lengths ¿C15. Moreover, from experience gained in tests that have been conducted with substances in this category, considerable technical difficulties would be expected in the conduct of such a test, due to the very rapid biotic removal of the substance from the test system. Therefore, long-term toxicity to fish requirements are waived based on technical testing difficulties, ready biodegradation and low to no short-term toxicity to aquatic organisms at the limit of solubility. No reliable measured or predicted long-term toxicity data to fish for constituents of Ziegler Bottoms is available.
Short-term Toxicity to Invertebrates
The short-term toxicity in invertebrates of components of Ziegler Bottoms has been documented within this dossier. In a conservative approach the most sensitive study result from across the two constituents has been identified and used to address the hazard endpoint in question. The most sensitive study result from across the two substances has been identified as a reliable study with docosan-1-ol (Fisk et al., 2009) where the 96 hr LC50 was predicted at >100 mg/L. However, the predicted LC50 is greater than the limit of solubility (>LoS, which is 0.1 mg/L). It is concluded that under circumstances when the predicted LC50 is greater than the LoS, the substance is not considered to be toxic.
Long-term Toxicity to Invertebrates
In accordance with REACH Annex XI, section 1, testing does not appear scientifically necessary for Annex endpoint 9.1.5. Sufficient information is available to predict an absence of toxicity at the limit of solubility for linear alcohols with carbon chain lengths ¿C15. Moreover, from experience gained in tests that have been conducted with substances in this category, considerable technical difficulties would be expected in the conduct of such a test, due to the very rapid biotic removal of the substance from the test system. Therefore, long-term toxicity to invertebrate requirements are waived based on technical testing difficulties, ready biodegradation and low to no short-term toxicity to aquatic organisms at the limit of solubility. No reliable measured or predicted long-term toxicity data to fish for constituents of Ziegler Bottoms is available.
Toxicity to Aquatic Algae
The toxicity to algae of components of Ziegler Bottoms has been documented within this dossier. Adequate reliable predicted data exists for toxicity to algae to components of Ziegler Bottoms (namely, icosan-1-ol and docosan-1-ol). In a conservative approach the most sensitive study result from across the two constituents has been identified and used to address the hazard endpoint in question. Both constituents are considered non-toxic at the limit of solubility. Therefore, the value used as key in the assessment is the EC50 of >0.001 mg/L which is at the limit of solubility for both docosan-1-ol and icosan-1-ol.
Toxicity to Microorganisms
Ziegler Bottoms are characterized as comprising of two primary constituents; icosan-1-ol and docosan-1-ol. Together these primary constituents represent a structural class of components (alcohols) that constitute approximately 82% of the composition of Ziegler Bottoms. Study data, where available, for each of these primary constituents has been evaluated and considered together. In a conservative approach the most sensitive study result from across the two constituents has been identified and used to adequately address the Ziegler Bottoms endpoint in question.
In accordance with Column 2 of REACH Annex VIII, the activated sludge respiration inhibition study (required in Section 9.1.4) does not need to be conducted as the substance is readily biodegradable and the applied test concentrations are in the range that can be expected in the influent to a sewage treatment plant.
Since the most sensitive study result across the two Ziegler Bottoms constituents was used to represent the toxicity of Ziegler Bottoms, it is deemed that this approach would be protective of the environment.Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
