Registration Dossier
Registration Dossier
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EC number: 255-670-9 | CAS number: 42125-46-2
Endpoint summary
Administrative data
Key value for chemical safety assessment
Additional information
t.-Butylcyclohexylchlorformate was tested in the standard plate test as well as in the preincubation assay with and without metabolic activation (MA) in S. typhimurium TA98, TA100, TA1535 and TA1537 as well as in E. coli WP2uvrA at dose levels of 20 -5000 μg/plate. The study is conducted according to the OECD Guideline 471, respectively and is reliable with out any restriction. No increase in the number of revertants was detected in any strain with and without MA. Vehicle controls and positive controls were valid. Cytotoxicity was found depending on the strain in concentrations above 500 µg/plate.No precipitation was seen even at any dose level. t.-Butylcyclohexylchlorformateis not mutagenic in the Salmonella typhimurium/ Escherichia coli reverse mutation assay (Ames Test).
Short description of key information:
t.-Butylcyclohexylchlorformateis not mutagenic in the Salmonella typhimurium/ Escherichia coli reverse mutation assay (Ames Test).
Endpoint Conclusion: No adverse effect observed (negative)
Justification for classification or non-classification
No classification is warranted concerning mutagenicity as classification criteria EU Regulation 67/548 (R23) and EU Regulation 1272/2008 are not met.
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