Registration Dossier
Registration Dossier
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EC number: 206-982-9 | CAS number: 407-25-0
Endpoint summary
Administrative data
Description of key information
Additional information
Trifluoroacetic acid anhydride (TFAH) reacts violently with water and is instantaneously degraded in trifluoroacetic acid (TFA) which is the relevant substance for risk assessment and classification & labelling purposes.
In aqueous solution, the pH of the substance is naturally low and for testing on organisms either the sodium salt (NaTFA) or pH adjustment were required.
Two key studies are available for NaTFA, performed according to OECD 208 guideline on three different plants species. The lowest EC50 was measured for shoot growth of mung bean at 4.7 mg/kg DW and the NOEC was determined at 0.83 mg/kg DW for the three species.
No relevant data are available on soil macroorganisms, terrestrial arthropods and soil microorganisms. It is assumed that there is no need to conduct this studies on TFAH based on low exposure and low toxicity considerations. Indeed, the substance have a low potential for bioaccumulation (Log Kow < 3, not highly adsorptive, Log Koc = 10 L/Kg (estimated by Kocwin v2.00 with MCI method) or 4.026 L/Kg (estimated by Kocwin v2.00 with Kow method)).
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
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