Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Ecotoxicological information

Endpoint summary

Administrative data

Description of key information

Additional information

Trifluoroacetic acid anhydride (TFAH) reacts violently with water and is instantaneously degraded in trifluoroacetic acid (TFA) which is the relevant substance for risk assessment and classification & labelling purposes.

In aqueous solution, the pH of the substance is naturally low and for testing on organisms either the sodium salt (NaTFA) or pH adjustment were required.

Two key studies are available for NaTFA, performed according to OECD 208 guideline on three different plants species. The lowest EC50 was measured for shoot growth of mung bean at 4.7 mg/kg DW and the NOEC was determined at 0.83 mg/kg DW for the three species.

No relevant data are available on soil macroorganisms, terrestrial arthropods and soil microorganisms. It is assumed that there is no need to conduct this studies on TFAH based on low exposure and low toxicity considerations. Indeed, the substance have a low potential for bioaccumulation (Log Kow < 3, not highly adsorptive, Log Koc = 10 L/Kg (estimated by Kocwin v2.00 with MCI method) or 4.026 L/Kg (estimated by Kocwin v2.00 with Kow method)).