Registration Dossier

Toxicological information

Acute Toxicity: oral

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Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
4 (not assignable)

Data source

Reference
Reference Type:
publication
Title:
Iodoquinol associated seizures and radiopacity.
Author:
Fisher AK, Walter FG, Szabo S.
Year:
1993
Bibliographic source:
Clinical Toxicology, 1993, Vol. 31, No. 1 : Pages 113-120

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: not available
GLP compliance:
not specified
Test type:
other: no data

Test material

Constituent 1
Chemical structure
Reference substance name:
Diiodohydroxyquinoline
EC Number:
201-497-9
EC Name:
Diiodohydroxyquinoline
Cas Number:
83-73-8
Molecular formula:
C9H5I2NO
IUPAC Name:
5,7-diiodoquinolin-8-ol

Test animals

Species:
other: Human child
Sex:
not specified

Administration / exposure

Route of administration:
oral: unspecified
Vehicle:
not specified
Details on oral exposure:
intervals of 13 Days
Doses:
819 mg/kg/13 Days
Control animals:
not specified

Results and discussion

Effect levels
Sex:
not specified
Dose descriptor:
LDLo
Effect level:
819 mg/kg bw
Clinical signs:
no data
Body weight:
no data
Gross pathology:
no data
Other findings:
no data

Any other information on results incl. tables

TOXIC EFFECTS :

Behavioral - somnolence (general depressed activity)

Behavioral - convulsions or effect on seizure threshold

Blood - oxidant related (GPD deficient) anemia

Applicant's summary and conclusion

Interpretation of results:
other: not specified
Remarks:
Criteria used for interpretation of results: not specified
Conclusions:
Acute toxicity by Oral route examined at dose concentration 819 mg/kg bw