Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 201-497-9 | CAS number: 83-73-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Link to relevant study records
- Endpoint:
- chronic toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 4 (not assignable)
- Qualifier:
- according to guideline
- Guideline:
- other:
- Principles of method if other than guideline:
- Data is from RTECS ,SAX handbook and ACToR database.
- GLP compliance:
- not specified
- Species:
- other: Human
- Strain:
- other: not applicable
- Sex:
- not specified
- Route of administration:
- oral: unspecified
- Vehicle:
- not specified
- Analytical verification of doses or concentrations:
- not specified
- Duration of treatment / exposure:
- 2 years
- Frequency of treatment:
- intermittent frequency
- Dose descriptor:
- other: TDLo
- Effect level:
- 120 000 other: mg/kg
- Based on:
- test mat.
- Sex:
- not specified
- Basis for effect level:
- other: Sense Organs and Special Senses (Eye) - visual field changes
- Critical effects observed:
- not specified
- Conclusions:
- Repeated dose oral toxicity value of diiodohydroxyquinoline to Human - child was found to be TDLo(Lowest published toxic dose): 120000 mg/kg, when diiodohydroxyquinoline was administered orally for 2 years.
- Executive summary:
Repeated dose oral toxicity value of diiodohydroxyquinoline to Human - child was found to be TDLo(Lowest published toxic dose): 120000 mg/kg, when diiodohydroxyquinoline was administered orally for 2 years.
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
- Study duration:
- chronic
- Species:
- other: human
- Quality of whole database:
- Data is from a long term study (2 years) wherein the TDLo was found to be greater than 120000 mg/kg body weight in humans
Repeated dose toxicity: inhalation - systemic effects
Link to relevant study records
- Endpoint:
- repeated dose toxicity: inhalation
- Data waiving:
- exposure considerations
- Justification for data waiving:
- other:
- Critical effects observed:
- not specified
Reference
Endpoint conclusion
- Endpoint conclusion:
- no adverse effect observed
Repeated dose toxicity: dermal - systemic effects
Link to relevant study records
- Endpoint:
- repeated dose toxicity: dermal
- Data waiving:
- other justification
- Justification for data waiving:
- other:
- Critical effects observed:
- not specified
Reference
Endpoint conclusion
- Endpoint conclusion:
- no study available
Additional information
Justification for selection of repeated dose toxicity via oral route - systemic effects endpoint:
Data is from a long term study (2 years) wherein the TDLo was found to be greater than 120000 mg/kg body weight in humans
Justification for selection of repeated dose toxicity inhalation - systemic effects endpoint:
The low vapour pressure of the chemical diiodohydroxyquinoline shall ensure that the exposure to vapours shall be negliglible and therefore it is expected that the chemical shall not exhibit repeated dose toxicity by the inhalation route.
Justification for selection of repeated dose toxicity dermal - systemic effects endpoint:
From the acute dermal study results and also considering the fact that the chemical diiodohydroxyquinoline is used as a skin antiseptic it is assumed that the chemical shall not exhibit repeated dose toxicity by the dermal route in low concentrations.
Justification for classification or non-classification
The data for repeated dose toxicity by the oral route is from a long term study (2 years) wherein the TDLo was found to be greater than 120000 mg/kg body weight in humans. Given that the oral route of exposure is considered to be the most prominent route of exposure, it is concluded that the chemical shall not exhibit repeated dose toxicity via the oral, inhalation and dermal route.
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