Lanthanum trinitrate

Acute Toxicity: oral

Administrative data

Endpoint:

acute toxicity: oral

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: see 'Remark'

Remarks:

Well documented, scientifically sound study with methods similar to OECD 401 with the following deviations: The number of deaths at each dose were not reported; the specific doses (mg/kg) were not provided; individual clinical observations, body weights, pathology were not reported; sex of the animals was not provided

Data source

Reference

Reference 1

Reference Type:

publication

Title:

Acute toxicity of zirconium, columbium, strontium, lanthanum, cesium, tantalum, and yttrium

Author:

Cochran KW, Doull J, Mazur M, DuBois KP.

Year:

1950

Bibliographic source:

Industrial Hygiene and Occupational Medicine 1: 637-650,

Reference 2

Reference Type:

secondary source

Title:

Sax's Dangerous Properties of Industrial Materials

Author:

Lewis

Year:

1995

Bibliographic source:

9th ed, Van Nostrand Reinhold, New York, page 2021, ref. AIHOAX 1,637,50

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 401 (Acute Oral Toxicity)

Deviations:

yes

Remarks:

The number of deaths at each dose were not reported; the specific doses (mg/kg) were not provided; individual clinical observations, body weights, pathology were not reported; sex of the animals was not provided

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Lanthanum trinitrate

EC Number:

233-238-0

EC Name:

Lanthanum trinitrate

Cas Number:

10099-59-9

Molecular formula:

H3LaN3O9+3

IUPAC Name:

lanthanum trinitrate

Details on test material:

- Name of test material (as cited in study report): Lanthanum nitrate

Test animals

Species:

rat

Strain:

Sprague-Dawley

Sex:

male/female

Details on test animals or test system and environmental conditions:

TEST ANIMALS
- Source: no data
- Age at study initiation: adult
- Weight at study initiation: between 200 and 300 g
- Fasting period before study: no data
- Housing: no data
- Diet (e.g. ad libitum): ad libitum
- Water (e.g. ad libitum): ad libitum
- Acclimation period: no data

ENVIRONMENTAL CONDITIONS
Animals were maintained in air conditioned rooms.

Administration / exposure

Route of administration:

oral: gavage

Vehicle:

water

Details on oral exposure:

VEHICLE
- Concentration in vehicle: 50% solution

Doses:

The solution was given in single doses by stomach tube. No further information on doses provided.

No. of animals per sex per dose:

24 rats in total

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: All animals were observed for 10 days. An initial group of animals receiving the test substance were kept for 30 days to verify if any significant mortality occurred after the tenth day.
- Frequency of observations and weighing: no data
- Necropsy of survivors performed: no data

Statistics:

The LD50 values were obtained from ten day mortality data by using the log-probability method.

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

4 500 mg/kg bw

Based on:

test mat.

Remarks on result:

other: i.e. 1450 mg La/kg bw

Mortality:

No further details reported. No sex differences were noted.

Clinical signs:

other: No further details reported.

Gross pathology:

No data

Applicant's summary and conclusion

Interpretation of results:

not classified

Remarks:

Migrated information Criteria used for interpretation of results: EU

Conclusions:

The oral LD50 was calculated to be 4500 mg compound/kg bw.