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Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: not guideline compliant and irrelevant administration route

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Principles of method if other than guideline:
Intraperitoneal injection
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2-hydroxy-2-methylpropiophenone
EC Number:
231-272-0
EC Name:
2-hydroxy-2-methylpropiophenone
Cas Number:
7473-98-5
Molecular formula:
C10H12O2
IUPAC Name:
2-hydroxy-2-methyl-1-phenylpropan-1-one

Test animals

Species:
rat
Strain:
Wistar
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
peanut oil
Doses:
Five doses between 4000 and 10000 mg/kg
No. of animals per sex per dose:
5
Control animals:
yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
824 mg/kg bw
Based on:
test mat.
Remarks on result:
other: calculated

Applicant's summary and conclusion

Conclusions:
After acute intraperitoneal injection of Darocur 1173 to Wistar rats, a LD50 of 824 mg/kg was calculated.