2-hydroxy-2-methylpropiophenone

Acute Toxicity: other routes

Administrative data

Endpoint:

acute toxicity: other routes

Type of information:

experimental study

Adequacy of study:

supporting study

Study period:

1980

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: not guideline compliant and irrelevant administration route

Data source

Reference

Reference Type:

study report

Title:

Unnamed

Year:

1980

Report date:

1980

Materials and methods

Principles of method if other than guideline:

Intraperitoneal injection

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

2-hydroxy-2-methylpropiophenone

EC Number:

231-272-0

EC Name:

2-hydroxy-2-methylpropiophenone

Cas Number:

7473-98-5

Molecular formula:

C10H12O2

IUPAC Name:

2-hydroxy-2-methyl-1-phenylpropan-1-one

Test animals

Species:

rat

Strain:

Wistar

Sex:

male/female

Administration / exposure

Route of administration:

intraperitoneal

Vehicle:

peanut oil

Doses:

Five doses between 4000 and 10000 mg/kg

No. of animals per sex per dose:

5

Control animals:

yes

Results and discussion

Effect levels

Sex:

male/female

Dose descriptor:

LD50

Effect level:

824 mg/kg bw

Based on:

test mat.

Remarks on result:

other: calculated

Applicant's summary and conclusion

Conclusions:

After acute intraperitoneal injection of Darocur 1173 to Wistar rats, a LD50 of 824 mg/kg was calculated.