Registration Dossier

Diss Factsheets

Administrative data

Endpoint:
acute toxicity: other routes
Type of information:
experimental study
Adequacy of study:
supporting study
Study period:
1979 - 1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Acceptable, well documented report which meets basic scientific principles.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Principles of method if other than guideline:
other: BASF-Test
GLP compliance:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
2,2-dimethyloxirane
EC Number:
209-193-8
EC Name:
2,2-dimethyloxirane
Cas Number:
558-30-5
Molecular formula:
C4H8O
IUPAC Name:
2,2-dimethyloxirane
Details on test material:
- Name of test material: iso Butylenoxid
- Lot/batch No.: 78/874 (Substance-No.)
- Other: Test substance: as prescribed by 1.1 - 1.4

Test animals

Species:
mouse
Strain:
NMRI
Sex:
male/female

Administration / exposure

Route of administration:
intraperitoneal
Vehicle:
CMC (carboxymethyl cellulose)
Details on exposure:
2-20% emulsion in aqueous 0.5 % carboxymethyl cellulose
Doses:
200, 700, 2000 mg/kg bw
No. of animals per sex per dose:
5 animals
Control animals:
no
Details on study design:
- Duration of observation period following administration: 14 days
- Frequency of observations: several times on the day of application and daily thereafter
- Necropsy of survivors performed: yes

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
> 700 - < 2 000 mg/kg bw
Based on:
test mat.

Any other information on results incl. tables

After application of 200 and 700 mg/kg bw 0/5 animals died.

After application of 2000 mg/kg bw 5/5 animals died after 1 hour.

Applicant's summary and conclusion

Executive summary:

In an acute intraperitoneal toxicity study according to an internal BASF method (BASF AG, 1980), animals were given a single dose of 2,2-dimethyloxirane i.p. (2, 7 and 20 % emulsion in aqueous 0.5 % carboxymethyl cellulose) at 200, 700 and 2000 mg/kg bw. Mice were then observed for mortality and for clinical symptoms of toxicity for 14 days. All animals were subjected to necropsy. The LD50 was estimated as >700 and < 2000 mg/kg bw. This acute intraperitoneal study is classified as acceptable.