Registration Dossier
Registration Dossier
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EC number: 209-193-8 | CAS number: 558-30-5
Acute Toxicity: other routes
Administrative data
- Endpoint:
- acute toxicity: other routes
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Study period:
- 1979 - 1980
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Acceptable, well documented report which meets basic scientific principles.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 980
- Report date:
- 1980
Materials and methods
- Principles of method if other than guideline:
- other: BASF-Test
- GLP compliance:
- no
Test material
- Reference substance name:
- 2,2-dimethyloxirane
- EC Number:
- 209-193-8
- EC Name:
- 2,2-dimethyloxirane
- Cas Number:
- 558-30-5
- Molecular formula:
- C4H8O
- IUPAC Name:
- 2,2-dimethyloxirane
- Details on test material:
- - Name of test material: iso Butylenoxid
- Lot/batch No.: 78/874 (Substance-No.)
- Other: Test substance: as prescribed by 1.1 - 1.4
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- NMRI
- Sex:
- male/female
Administration / exposure
- Route of administration:
- intraperitoneal
- Vehicle:
- CMC (carboxymethyl cellulose)
- Details on exposure:
- 2-20% emulsion in aqueous 0.5 % carboxymethyl cellulose
- Doses:
- 200, 700, 2000 mg/kg bw
- No. of animals per sex per dose:
- 5 animals
- Control animals:
- no
- Details on study design:
- - Duration of observation period following administration: 14 days
- Frequency of observations: several times on the day of application and daily thereafter
- Necropsy of survivors performed: yes
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 700 - < 2 000 mg/kg bw
- Based on:
- test mat.
Any other information on results incl. tables
After application of 200 and 700 mg/kg bw 0/5 animals died.
After application of 2000 mg/kg bw 5/5 animals died after 1 hour.
Applicant's summary and conclusion
- Executive summary:
In an acute intraperitoneal toxicity study according to an internal BASF method (BASF AG, 1980), animals were given a single dose of 2,2-dimethyloxirane i.p. (2, 7 and 20 % emulsion in aqueous 0.5 % carboxymethyl cellulose) at 200, 700 and 2000 mg/kg bw. Mice were then observed for mortality and for clinical symptoms of toxicity for 14 days. All animals were subjected to necropsy. The LD50 was estimated as >700 and < 2000 mg/kg bw. This acute intraperitoneal study is classified as acceptable.
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