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Environmental fate & pathways

Hydrolysis

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Reference
Endpoint:
hydrolysis
Type of information:
calculation (if not (Q)SAR)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
accepted calculation method
Justification for type of information:
Estimated data generated using the EPI Suite model developed by the USEPA.
Qualifier:
according to guideline
Guideline:
other: Modeling database
Principles of method if other than guideline:
HYDROWIN Program (v2.00) from EPI Suite estimation database
GLP compliance:
not specified
Radiolabelling:
not specified
Analytical monitoring:
not specified
Estimation method (if used):
HYDROWIN v2.00
Transformation products:
not specified
pH:
8
Temp.:
25 °C
Hydrolysis rate constant:
0.062 s-1
Remarks on result:
other: other details not available
pH:
7
Temp.:
25 °C
DT50:
3.54 yr
Remarks on result:
other: other details not available
pH:
8
Temp.:
25 °C
DT50:
129.295 d
Remarks on result:
other: other details not available
Validity criteria fulfilled:
not specified
Conclusions:
Hydrolysis rate constant of test chemical at pH 8 at 25 deg C was estimtaed to be 6.204E-002 L/mol-sec and half life of hydrolysis at pH 8 was estimated to be 129.295 days and at pH 7 3.540 years. By considering half life value it is concluded that test chemical is not hydrolysable.
Executive summary:

Hydrolysis rate constant of test chemical at  pH  8 at 25 deg C was estimtaed to be 6.204E-002 L/mol-sec and half life of hydrolysis  at pH 8 was estimated to be 129.295 days and at pH 7  3.540 years. By considering half life value it is concluded that test chemical is not hydrolysable.

Description of key information

Hydrolysis rate constant of test chemical at  pH  8 at 25 deg C was estimtaed to be 6.204E-002 L/mol-sec and half life of hydrolysis  at pH 8 was estimated to be 129.295 days and at pH 7  3.540 years. By considering half life value it is concluded that test chemical is not hydrolysable.

Key value for chemical safety assessment

Half-life for hydrolysis:
3.54 yr
at the temperature of:
25 °C

Additional information

Prediction and experimental studies have been reviewed from different sources of test chemical and its structurally similar read across chemical for Half life of hydrolysis in water endpoint and their results are summarized below.

In first study the Hydrowin of EPI suite was used for the prediction in this the Hydrolysis rate constant of test chemical at  pH  8 at 25 deg C was estimated to be 6.204E-002 L/mol-sec and half life of hydrolysis  at pH 8 was estimated to be 129.295 days and at pH 7  3.540 years.

Next study was reviewed from authoritative database (HSDB) in this study the base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be 0.03L/mol-sec with corresponding half-lives of 7.3 yrs and 266 days at pH 7 and 8, respectively.

Last study was also reviewed from authoritative database (HSDB) in this study the base catalyzed second order hydrolysis rate constant was determined using a structure estimation method of the test chemical. The second order hydrolysis rate constant of test chemical was determined to be  2.9X10-2L/mol-sec with a corresponding half-lives of 7.7 yrs and 280 days at pH 7 and 8, respectively.

By considering the half life of hydrolysis values of all the studies mentioned above it is concluded that the test chemical is not hydrolysable.