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Long-term toxicity to aquatic invertebrates

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Reference
Endpoint:
long-term toxicity to aquatic invertebrates
Type of information:
read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
data from handbook or collection of data
Remarks:
Experimental data of various test chemicals
Justification for type of information:
Data is from collection of data
Reason / purpose for cross-reference:
read-across source
Reason / purpose for cross-reference:
read-across source
Qualifier:
according to guideline
Guideline:
other: as mentioned below
Principles of method if other than guideline:
WoE report is based on two long term toxicity study of aquatic invertebrate for the test chemical :
1. and 2. Long term toxicity study of test material was performed
GLP compliance:
no
Analytical monitoring:
no
Vehicle:
no
Test organisms (species):
Daphnia magna
Details on test organisms:
- Common name: Water flea
Test type:
semi-static
Water media type:
freshwater
Total exposure duration:
21 d
Reference substance (positive control):
not specified
Key result
Duration:
21 d
Dose descriptor:
EC50
Effect conc.:
1.5 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
reproduction
Remarks on result:
other: Other details not known
Duration:
21 d
Dose descriptor:
EC50
Effect conc.:
> 0.55 - < 2 mg/L
Nominal / measured:
not specified
Conc. based on:
test mat.
Basis for effect:
reproduction
Validity criteria fulfilled:
no
Conclusions:
The test chemical is not likely to be toxic to invertebrate in long term atleast in the concentration range of 0.55 - 2 mg/l.
Executive summary:

Data available for the test chemicals has been reviewed to determine the long term toxicity of test chemical on aquatic invertebrate .The studies are as mentioned below:

The long term study of test material on aquatic invertebrate daphnia magna was performed to evalute its effect on reproduction efficiency of daphnia magna according to OECD Guideline 211 (Daphnia magna Reproduction Test). The EC50 of test material after 21 days was observed to be in the range of 0.55 - 2.1 mg/l. The no effect concentration (NOEC) was observed to be 0.55 mg/l. On the basis of above effect EC50 value chemical can be considered as non-toxic to fish and cannot be classified as hazardous as per the CLP criteria.

First study was supported by the second study from authoritative study. Long term toxicity of test chemical on invertebrate daphnia magna study was performed for 21 days according to OECD Guideline 211 (Daphnia magna Reproduction Test). Based on the effect observation on the daphnia magna after exposure period of 21 days, the EC50 was observed to be 1.5 mg/l, the NOEC was observed to be 0.48 mg/l. On the basis of above value it can be considered that the chemical was non-toxic to fish and cannot be classified as hazardous as per the CLP criteria.

Thus based on the above effects, chemical consider to be nontoxic and not classified sa per the CLP classification criteria.

Description of key information

The test chemical  is not likely to be toxic to invertebrate in long term atleast in the concentration range of 1.5 - 2 mg/l.

Key value for chemical safety assessment

Fresh water invertebrates

Fresh water invertebrates
Effect concentration:
0.55 mg/L

Additional information

Data available for the test chemicals and structurally similar read across chemical, study has been reviewed to determine the long term toxicity of test chemical on aquatic invertebrate .The studies are as mentioned below:

 

The long term study of test material on aquatic invertebrate daphnia magna was performed to evaluate its effect on reproduction efficiency of daphnia magna according to OECD Guideline 211 (Daphnia magna Reproduction Test). The EC50 of test material after 21 days was observed to be in the range of 0.55 - 2.1 mg/l. The no effect concentration (NOEC) was observed to be 0.55 mg/l. On the basis of above effect EC50 value chemical can be considered as non-toxic to fish and cannot be classified as hazardous as per the CLP criteria.

 

First study was supported by the second study from authoritative study. Long term toxicity of test chemical on invertebrate daphnia magna study was performed for 21 days according to OECD Guideline 211 (Daphnia magna Reproduction Test). Based on the effect observation on the daphnia magna after exposure period of 21 days, the EC50 was observed to be 1.5 mg/l, the NOEC was observed to be 0.48 mg/l. On the basis of above value it can be considered that the chemical was non-toxic to fish and cannot be classified as hazardous as per the CLP criteria.

 

Thus based on the above effects, chemical consider to be nontoxic and not classified as per the CLP classification criteria.

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