Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 207-325-9 | CAS number: 462-34-0
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

PBT assessment
Administrative data
PBT assessment: overall result
- PBT status:
- the substance is not PBT / vPvB
- Justification:
In contact with water, tetrahydrofuran - boron trifluoride rapidly decomposes to form tetrahydrofuran and boron trifluoride dihydrate. The PBT assessment was consequently based on the properties of the hydrolysis products.
Tetrahydrofurane:
Although tetrahydrofuran does not meet the screening criteria for non-persistence stipulated in the ECHA Guidance on information requirements and chemical safety assessment (Part C: PBT Assessment, ECHA 2008), it is not considered necessary to further evaluate persistence. Several studies have been identified showing inherent biodegradability.
The measured Log Kow of 0.45 in the OECD 107 test indicates that tetrahydrofuran does not exceed the screening criteria for bioaccumulation stipulated in the ECHA guidance on information requirements and chemical safety assessment (Part C: PBT Assessment, 2008). Therefore, tetrahydrofuran is not considered to be bioaccumulative (B) or very bioaccumulative (vB).
Experimental ecotoxicity data are available for tetrahydrofuran. Acute toxicity to three freshwater trophic levels was low (all EC/LC50 > 100 mg/l) and are not sufficiently low enough to meet the screening criteria for toxicity (T) as stipulated in the ECHA Guidance. The chronic toxicity data also confirm that tetrahydrofuran does not meet the screening criteria for toxicity (T).
tetrahydrofuran is therefore not considered to be toxic (T) under these criteria.
In conclusiontetrahydrofurane does not fulfill the PBT and vPvB criteria.
Boron trifluoride:
Boron trifluoride and its breakdown products are not expected to bioaccumulate in fish/earthworm tissues due to their high solubility and octanol-water partition coefficients which are quite low. Moreover due to the expected very short half-life in aqueous media (hydrolysis), boron trifluoride isnot expected to be persistent in aquatic and terrestrial media. Considering all those elements one can safely conclude that secondary poisoning is not expected as birds and terrestrial top predators will not be exposed to boron trifluoride and its breakdown products via food consumption.
- Boron trifluoride and its breakdown productsfulfil the Toxic criterion: concerning the aquatic compartment EC50 or LC50 > 0.1 mg/L and NOEC for mammals > 30 mg/kg food. However, Boron trifluoride is classified as R48.
In conclusion Boron trifluoride does not fulfil the PBT/vPvB criteria.
- Likely routes of exposure:
Because the substance does not fulfill the PBT and vPvB criteria, no emission characterisation is performed.
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