Registration Dossier
Registration Dossier
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EC number: 402-810-3 | CAS number: 17980-47-1 DYNASILAN BH N; DYNASILAN BSM 100 N; DYNASILAN NH 42
Endpoint summary
Administrative data
Description of key information
In a rat 28-day oral gavage study conducted using a protocol similar to OECD 407 and to GLP (Huntingdon Research Centre, 1988) the NOAEL for triethoxyisobutylsilane was at least 1000 mg/kg bw/day, as there were no adverse toxicological findings at this the only dose tested.
In a repeated nose-only inhalation study, conducted to OECD 413 and to GLP (Safepharm Laboratories, Ltd., 1992) the NOAEC for triethoxyisobutylsilane was at least 2.54 mg/l in rats.
There are no dermal data.
Key value for chemical safety assessment
Repeated dose toxicity: via oral route - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEL
- 1 000 mg/kg bw/day
- Study duration:
- subacute
- Species:
- rat
Repeated dose toxicity: inhalation - systemic effects
Endpoint conclusion
- Dose descriptor:
- NOAEC
- 2 540 mg/m³
- Study duration:
- subchronic
- Species:
- rat
Additional information
The key and supporting studies for triethoxyisobutylsilane show that this substance has a low potential to cause adverse health effects.
Justification for classification or non-classification
Based on the available oral and inhalation repeated dose toxicity studies, triethoxyisobutylsilane is not classified for specific target organ toxicity following repeated exposure according to Regulation 1272/2008/EC.
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