Registration Dossier
Registration Dossier
Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.
The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 279-791-1 | CAS number: 81646-13-1
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 3 (not reliable)
- Rationale for reliability incl. deficiencies:
- other: non-guideline experimental human study, low test substance concentration
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 1 986
- Report date:
- 1986
Materials and methods
- Study type:
- study with volunteers
- Endpoint addressed:
- skin irritation / corrosion
- Principles of method if other than guideline:
- Epicutaneous patch test
Test material
- Reference substance name:
- Quaternary ammonium compounds, C20-22-alkyltrimethyl, chlorides
- EC Number:
- 271-756-9
- EC Name:
- Quaternary ammonium compounds, C20-22-alkyltrimethyl, chlorides
- Cas Number:
- 68607-24-9
- IUPAC Name:
- 68607-24-9
Constituent 1
Method
- Type of population:
- general
- Subjects:
- Test type: Epicutaneous patch test with 1.0 % behentrimonium chloride in water
Subjects: Healthy male and female volunteers, age 17-80 years, nine of which with allergies, without visible skin lesions at the start of the study
Group size: 19 male and 31 female subjects - Route of exposure:
- dermal
- Reason of exposure:
- intentional
- Details on exposure:
- 1.0 % behentrimonium chloride in water
The test substance was applied to the skin of the back using usual test chambers. The test site was covered occlusively by adhesive plaster for 24 hours. - Examinations:
- - Other: Skin reactions were evaluated 0 and 24 hours after removal of test patches.
Results and discussion
- Results of examinations:
- No signs of skin irritation were detected in any subject at 0 as well as at 24 hours after application.
Applicant's summary and conclusion
- Conclusions:
- 1.0 % behentrimonium chloride in water produced no skin irritation when applied under occlusion for 24 hours in a human epicutaneous patch test.
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