Registration Dossier
Registration Dossier
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EC number: 279-791-1 | CAS number: 81646-13-1
Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Type of information:
- migrated information: read-across from supporting substance (structural analogue or surrogate)
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Only short abstract available - Only secondary literature. Justification for read-across see chapter 1 of the chemical safety report.
Data source
Reference
- Reference Type:
- secondary source
- Title:
- Ref. 6.1 in: Inclusion of active substances in Annex I to Directive 98/8/EC - Draft Assessment Report - Didecyldimethylammonium chloride - Product-type 8 (Wood preservative) - Rapporteur Member State: Italy
- Author:
- RMS Italy
- Year:
- 2 007
- Bibliographic source:
- http://circa.europa.eu/Public/irc/env/bio_reports/library?l=/review_programme/ca_reports/wood_preservatives/published_10102007&vm=detailed&sb=Title
Materials and methods
- Principles of method if other than guideline:
- Acute dermal toxicity study in rabbits
- GLP compliance:
- not specified
- Test type:
- standard acute method
Test material
- Reference substance name:
- Didecyldimethylammonium chloride
- EC Number:
- 230-525-2
- EC Name:
- Didecyldimethylammonium chloride
- Cas Number:
- 7173-51-5
- IUPAC Name:
- N-decyl-N,N-dimethyldecan-1-aminium chloride
- Details on test material:
- - Name of test material (as cited in study report): 80% solution of DDAC (didecyldimethyl ammonium chloride)
Constituent 1
Test animals
- Species:
- rat
Results and discussion
Effect levels
- Dose descriptor:
- LD50
- Effect level:
- 3 342 mg/kg bw
Applicant's summary and conclusion
- Conclusions:
- In a acute dermal toxicity study in rabbits with didecyldimethyl ammonium chloride, the LD50 was 3342 mg/kg bw.
- Executive summary:
In a acute dermal toxicity study in rabbits with didecyldimethyl ammonium chloride, the LD50 was 3342 mg/kg bw.
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