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Toxicological information

Acute Toxicity: dermal

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Administrative data

Endpoint:
acute toxicity: dermal
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
supporting study
Reliability:
4 (not assignable)
Rationale for reliability incl. deficiencies:
other: Only short abstract available - Only secondary literature. Justification for read-across see chapter 1 of the chemical safety report.

Data source

Reference
Reference Type:
secondary source
Title:
Ref. 6.1 in: Inclusion of active substances in Annex I to Directive 98/8/EC - Draft Assessment Report - Didecyldimethylammonium chloride - Product-type 8 (Wood preservative) - Rapporteur Member State: Italy
Author:
RMS Italy
Year:
2007
Bibliographic source:
http://circa.europa.eu/Public/irc/env/bio_reports/library?l=/review_programme/ca_reports/wood_preservatives/published_10102007&vm=detailed&sb=Title

Materials and methods

Principles of method if other than guideline:
Acute dermal toxicity study in rabbits
GLP compliance:
not specified
Test type:
standard acute method

Test material

Constituent 1
Reference substance name:
Didecyldimethylammonium chloride
EC Number:
230-525-2
EC Name:
Didecyldimethylammonium chloride
Cas Number:
7173-51-5
IUPAC Name:
N-decyl-N,N-dimethyldecan-1-aminium chloride
Details on test material:
- Name of test material (as cited in study report): 80% solution of DDAC (didecyldimethyl ammonium chloride)

Test animals

Species:
rat

Results and discussion

Effect levels
Dose descriptor:
LD50
Effect level:
3 342 mg/kg bw

Applicant's summary and conclusion

Conclusions:
In a acute dermal toxicity study in rabbits with didecyldimethyl ammonium chloride, the LD50 was 3342 mg/kg bw.
Executive summary:

In a acute dermal toxicity study in rabbits with didecyldimethyl ammonium chloride, the LD50 was 3342 mg/kg bw.