Registration Dossier
Registration Dossier
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The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.
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EC number: 244-815-1 | CAS number: 22174-70-5
Toxicological Summary
Administrative data
Workers - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 13.2 mg/m³
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other:
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 987 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Workers - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 1.87 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other:
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 560 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
Workers - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - workers
General Population - Hazard via inhalation route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 2.32 mg/m³
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other:
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEC
- Value:
- 348 mg/m³
- Explanation for the modification of the dose descriptor starting point:
Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard via dermal route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.667 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other:
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
Local effects
Long term exposure
- Hazard assessment conclusion:
- no hazard identified
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
General Population - Hazard via oral route
Systemic effects
Long term exposure
- Hazard assessment conclusion:
- DNEL (Derived No Effect Level)
- Value:
- 0.667 mg/kg bw/day
- Most sensitive endpoint:
- effect on fertility
- Route of original study:
- Oral
DNEL related information
- DNEL derivation method:
- other:
- Dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- Modified dose descriptor starting point:
- NOAEL
- Value:
- 400 mg/kg bw/day
- Explanation for the modification of the dose descriptor starting point:
Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
- Justification:
- Default (DNEL calculator)
Acute/short term exposure
- Hazard assessment conclusion:
- no hazard identified
DNEL related information
General Population - Hazard for the eyes
Local effects
- Hazard assessment conclusion:
- no hazard identified
Additional information - General Population
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
