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Description of key information

None of the category members has an oral or dermal LD50 < 2000 mg/kg bw. Inhalation effects are not expected among category members, because no exposure is expected basing on the low vapour pressure of the substances.

Key value for chemical safety assessment

Acute toxicity: via oral route

Link to relevant study records
Reference
Endpoint:
acute toxicity: oral
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Justification for type of information:
Adipic acid diesters category. See attached report.
Key result
Sex:
not specified
Dose descriptor:
LD50
Effect level:
> 2 000 mg/kg bw
Based on:
not specified
Remarks on result:
other: Non of the category members with acute oral toxicity data has a LD50 lower than 5000 mg/kg bw
Interpretation of results:
not classified
Remarks:
Migrated information
Conclusions:
Non of the category members with acute oral toxicity data has a LD50 lower than 5000 mg/kg bw.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
LD50
Value:
2 000 mg/kg bw

Acute toxicity: via inhalation route

Link to relevant study records
Reference
Endpoint:
acute toxicity: inhalation
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Justification for type of information:
Adipic acid diesters category. See attached report.
Duration of exposure:
h
Remarks on result:
not measured/tested
Conclusions:
All category members have a very low vapour pressure, therefore human exposure via inhalation is not foreseen. However, no molrtality was observed in rats exposed to air saturated with bis(2-ethylhexyl)adipate and with dibutyl adipate.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed

Acute toxicity: via dermal route

Link to relevant study records
Reference
Endpoint:
acute toxicity: dermal
Type of information:
read-across based on grouping of substances (category approach)
Adequacy of study:
weight of evidence
Justification for type of information:
Adipi acid diesters category. See attached report.
Key result
Effect level:
> 2 000 mg/kg bw
Remarks on result:
not determinable due to absence of adverse toxic effects
Interpretation of results:
GHS criteria not met
Conclusions:
None of the category members has a dermal LD50 lower than 2000 mg/kg bw.
Endpoint conclusion
Endpoint conclusion:
no adverse effect observed
Dose descriptor:
discriminating dose
Value:
2 000 mg/kg bw

Additional information

Justification for classification or non-classification

Basing on the available acute toxicity data, based on a read-across approach with the adipic acid diesters category, bis[2-[2-(2-butoxyethoxy)ethoxy]ethyl]adipate is not classified for acute toxicity according to Regulation (EC) n. 1272/2008.

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