Registration Dossier
Registration Dossier
Diss Factsheets
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EC number: 202-488-2 | CAS number: 96-20-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Skin irritation / corrosion
Administrative data
- Endpoint:
- skin irritation / corrosion
- Remarks:
- in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: Study report is limited to a single page with no methods, no description of the results or number of animals used. It simply states the study outcome. There are no other data available for this endpoint.
Data source
Reference
- Reference Type:
- other company data
- Title:
- Unnamed
- Year:
- 1 974
- Report date:
- 1974
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- EU Method B.40 (In Vitro Skin Corrosion: Transcutaneous Electrical Resistance Test (TER))
- Principles of method if other than guideline:
- No information given on methods
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-aminobutan-1-ol
- EC Number:
- 202-488-2
- EC Name:
- 2-aminobutan-1-ol
- Cas Number:
- 96-20-8
- Molecular formula:
- C4H11NO
- IUPAC Name:
- 2-aminobutan-1-ol
- Details on test material:
- 79.4% purity
Constituent 1
Test animals
- Species:
- rabbit
- Strain:
- not specified
Test system
- Type of coverage:
- occlusive
- Preparation of test site:
- shaved
- Vehicle:
- unchanged (no vehicle)
- Controls:
- no
- Amount / concentration applied:
- 0.5 ml of test material as received
- Duration of treatment / exposure:
- 4 Hours
- Observation period:
- Immediately after removal of Dressing
- Number of animals:
- 6
Results and discussion
In vivo
- Irritant / corrosive response data:
- Only the corrosivity was determined, as such no information is provided on individual animal scores for erythema and edema. The conclusion of the assay was that the material tested was corrosive, however there is no information on the time taken to produce corrosivity, i.e. 4 mins, 1 hour or 4 hours.
Considering the pH and the irritancy of the structurally related compound 2-amino-2-methylpropanol it is likely that it is corrsoive at 4 hours rather than 1 hours
Any other information on results incl. tables
Only the corrosivity was determined, as such no information is provided on individual animal scores for erythema and edema. The conclusion of the assay was that the material tested was corrosive.
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- The substance appears to be corosive. Considering the high pH of the test material in a 0.1M aqueous solution (pH11.1) it is not surprising that the substance is corrosive.
- Executive summary:
2 -Aminobutanol was tested for corrosivity using a Draize protocol, where 6 Albino Rabbits were exposed under occlusive conditions to the test material for 4 hours. Under the conditions of the assay the substance was Corrosive.
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