Registration Dossier

Diss Factsheets

Administrative data

Key value for chemical safety assessment

Additional information

No data is available for the registered substance, 2-(ethylthio)ethanol. A bacterial mutagenicity study is, however, available for the related substance, 2,2'-dithiobisethanol (CAS number 1892-29-1), which is a close structural analogue of 2 -(ethylthio)ethanol. It is considered appropriate to read across the results for 2,2'-dithiobisethanol because both are hydroxysulfides containing similar functional groups.

Short description of key information:
In vitro
Gene mutation (Bacterial reverse mutation assay / Ames test): read-across from related substance 2,2'-dithiobisethanol (CAS number 1892-29-1): negative with and without activation in all strains tested (similar to OECD TG 471)

Endpoint Conclusion:

Justification for classification or non-classification

There is evidence for lack of genotoxicity in bacterial cells for the related substance, 2,2'-dithiobisethanol, but studies on mammalian cells are not available and no data are available from testing in vivo. It is therefore not possible to reach a conclusion on genetic toxicity for the registered substance, 2 -(ethylthio)ethanol. In vivo testing is not proposed as the substance is a strictly controlled intermediate so exposure is not expected.