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Toxicological information

Genetic toxicity: in vitro

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Administrative data

Endpoint:
in vitro gene mutation study in bacteria
Remarks:
Type of genotoxicity: gene mutation
Type of information:
calculation (if not (Q)SAR)
Remarks:
Migrated phrase: estimated by calculation
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Reference Type:
other: Authoritative data base
Title:
Danish QSAR study for CAS No.: 137-51-9
Author:
Danish EPA Model
Year:
2012
Bibliographic source:
QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database; commercial

Materials and methods

Test guideline
Qualifier:
according to guideline
Guideline:
other: modelling database
Principles of method if other than guideline:
Ames mutagenicity. Multicase model A2H
GLP compliance:
no
Type of assay:
bacterial reverse mutation assay

Test material

Constituent 1
Chemical structure
Reference substance name:
4-aminobenzene-1,3-disulphonic acid
EC Number:
205-299-3
EC Name:
4-aminobenzene-1,3-disulphonic acid
Cas Number:
137-51-9
Molecular formula:
C6H7NO6S2
IUPAC Name:
4-aminobenzene-1,3-disulfonic acid
Details on test material:
- Name of test material : 4-aminobenzene-1,3-disulphonic acid
- Substance type: organic
- Physical state: solid

Method

Species / strain
Species / strain / cell type:
bacteria, other: Salmonella sp.
Additional strain / cell type characteristics:
not specified
Metabolic activation:
not specified

Results and discussion

Test results
Species / strain:
bacteria, other: Salmonella sp.
Metabolic activation:
not specified
Genotoxicity:
negative
Cytotoxicity / choice of top concentrations:
not specified
Vehicle controls validity:
not specified
Untreated negative controls validity:
not specified
Positive controls validity:
not specified
Remarks on result:
other: all strains/cell types tested
Remarks:
Migrated from field 'Test system'.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information):
negative

Based on the prediction for in-vitro bacterial reverse mutation assay (e.g. Ames test) on S. typhimurium sp. it was estimated that 4-aminobenzene-1,3-disulphonic acid was non mutagenic.
Executive summary:

Based on the prediction for in-vitro bacterial reverse mutation assay (e.g. Ames test) on S. typhimurium sp. it was estimated that 4-aminobenzene-1,3-disulphonic acid was non mutagenic.