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EC number: 205-299-3 | CAS number: 137-51-9
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro gene mutation study in bacteria
- Remarks:
- Type of genotoxicity: gene mutation
- Type of information:
- calculation (if not (Q)SAR)
- Remarks:
- Migrated phrase: estimated by calculation
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- other: Authoritative data base
- Title:
- Danish QSAR study for CAS No.: 137-51-9
- Author:
- Danish EPA Model
- Year:
- 2 012
- Bibliographic source:
- QSAR predictions by Danish Environmental Protection Agency (EPA)model powered by OASIS database; commercial
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: modelling database
- Principles of method if other than guideline:
- Ames mutagenicity. Multicase model A2H
- GLP compliance:
- no
- Type of assay:
- bacterial reverse mutation assay
Test material
- Reference substance name:
- 4-aminobenzene-1,3-disulphonic acid
- EC Number:
- 205-299-3
- EC Name:
- 4-aminobenzene-1,3-disulphonic acid
- Cas Number:
- 137-51-9
- Molecular formula:
- C6H7NO6S2
- IUPAC Name:
- 4-aminobenzene-1,3-disulfonic acid
- Details on test material:
- - Name of test material : 4-aminobenzene-1,3-disulphonic acid
- Substance type: organic
- Physical state: solid
Constituent 1
Method
Species / strain
- Species / strain / cell type:
- bacteria, other: Salmonella sp.
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- not specified
Results and discussion
Test results
- Species / strain:
- bacteria, other: Salmonella sp.
- Metabolic activation:
- not specified
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):
negative
Based on the prediction for in-vitro bacterial reverse mutation assay (e.g. Ames test) on S. typhimurium sp. it was estimated that 4-aminobenzene-1,3-disulphonic acid was non mutagenic. - Executive summary:
Based on the prediction for in-vitro bacterial reverse mutation assay (e.g. Ames test) on S. typhimurium sp. it was estimated that 4-aminobenzene-1,3-disulphonic acid was non mutagenic.
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