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EC number: 234-148-4 | CAS number: 10563-29-8
Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vitro / ex vivo
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail
Data source
Reference
- Reference Type:
- publication
- Title:
- Contribution of physicochemical properties to the evaluation of ocular irritation
- Author:
- Régnier JF and Imbert C
- Year:
- 1 992
- Bibliographic source:
- ATLA, 20: 457-465
Materials and methods
Test guideline
- Qualifier:
- no guideline available
- Principles of method if other than guideline:
- The method used permits the measurement of pH and acidic/alkaline reserve of all types of chemicals, under conditions which reproduce possible hydrolysis, in order to identify chemicals potentially corrosive to the eyes.
- GLP compliance:
- no
Test material
- Reference substance name:
- N'-(3-aminopropyl)-N,N-dimethylpropane-1,3-diamine
- EC Number:
- 234-148-4
- EC Name:
- N'-(3-aminopropyl)-N,N-dimethylpropane-1,3-diamine
- Cas Number:
- 10563-29-8
- Molecular formula:
- C8H21N3
- IUPAC Name:
- {3-[(3-aminopropyl)amino]propyl}dimethylamine
- Test material form:
- other: liquid
Constituent 1
Results and discussion
In vivo
Resultsopen allclose all
- Irritation parameter:
- other: pH
- Time point:
- other: -
- Score:
- 12
- Remarks on result:
- other: Considered to be potentially corrosive, based on pH and alkaline reserve measurements
- Irritation parameter:
- other: log(alkaline reserve)
- Time point:
- other: -
- Score:
- 1.76
- Irritation parameter:
- other: Index
- Time point:
- other: -
- Score:
- 13.7
Applicant's summary and conclusion
- Interpretation of results:
- corrosive
- Remarks:
- Migrated information Criteria used for interpretation of results: expert judgment
- Conclusions:
- Dimethyldipropylenetriamine is considered as potentially severely irritanting to the eye.
- Executive summary:
To evaluate the potential corrosivity for the eye of dimethyldipropylenetriamine, the pH and acidic/alkaline reserve was measured according to the method described by Régnier and Imbert (ATLA, 1992, 20, 457-465) and Froment (Arkema unpublished data, 1993). Under the test conditions, the results are as follow:
Test item
pH
log R (acidic/alkaline reserve
Physical-chemical index (I)
I = pH + log R, for pH ≥7
I = (14 -pH) + log R, for pH < 7
Dimethyldipropylenetriamine
11.9
1.6
13.5
According to the method, a substance is considered as potentially corrosive to the eye if at least 2 of the 3 following criteria are fulfilled:
pH≤ 2.5 or pH ≥9.5; log R ≥ 0 and /or I≥ 9.
Dimethyldipropylenetriamine is considered as potentially severely irritanting to the eye.
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