N'-(3-aminopropyl)-N,N-dimethylpropane-1,3-diamine

Eye irritation

Administrative data

Endpoint:

eye irritation: in vitro / ex vivo

Type of information:

experimental study

Adequacy of study:

key study

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

other: Test procedure in accordance with generally accepted scientific standards and described in sufficient detail

Data source

Reference

Reference Type:

publication

Title:

Contribution of physicochemical properties to the evaluation of ocular irritation

Author:

Régnier JF and Imbert C

Year:

1992

Bibliographic source:

ATLA, 20: 457-465

Materials and methods

Test guideline

Qualifier:

no guideline available

Principles of method if other than guideline:

The method used permits the measurement of pH and acidic/alkaline reserve of all types of chemicals, under conditions which reproduce possible hydrolysis, in order to identify chemicals potentially corrosive to the eyes.

GLP compliance:

no

Test material

Test material information

Constituent 1

Reference substance name:

N'-(3-aminopropyl)-N,N-dimethylpropane-1,3-diamine

EC Number:

234-148-4

EC Name:

N'-(3-aminopropyl)-N,N-dimethylpropane-1,3-diamine

Cas Number:

10563-29-8

Molecular formula:

C8H21N3

IUPAC Name:

{3-[(3-aminopropyl)amino]propyl}dimethylamine

Test material form:

other: liquid

Results and discussion

In vivo

Results

Results 1

Irritation parameter:

other: pH

Time point:

other: -

Score:

12

Remarks on result:

other: Considered to be potentially corrosive, based on pH and alkaline reserve measurements

Results 2

Irritation parameter:

other: log(alkaline reserve)

Time point:

other: -

Score:

1.76

Results 3

Irritation parameter:

other: Index

Time point:

other: -

Score:

13.7

Applicant's summary and conclusion

Interpretation of results:

corrosive

Remarks:

Migrated information Criteria used for interpretation of results: expert judgment

Conclusions:

Dimethyldipropylenetriamine is considered as potentially severely irritanting to the eye.

Executive summary:

To evaluate the potential corrosivity for the eye of dimethyldipropylenetriamine, the pH and acidic/alkaline reserve was measured according to the method described by Régnier and Imbert (ATLA, 1992, 20, 457-465) and Froment (Arkema unpublished data, 1993). Under the test conditions, the results are as follow:

Test item	pH	log R (acidic/alkaline reserve	Physical-chemical index (I) I = pH + log R, for pH ≥7 I = (14 -pH) + log R, for pH < 7
Dimethyldipropylenetriamine	11.9	1.6	13.5

According to the method, a substance is considered as potentially corrosive to the eye if at least 2 of the 3 following criteria are fulfilled:

pH≤ 2.5 or pH ≥9.5; log R ≥ 0 and /or I≥ 9.

Dimethyldipropylenetriamine is considered as potentially severely irritanting to the eye.