Registration Dossier

Diss Factsheets

Toxicological information

Genetic toxicity: in vitro

Currently viewing:

Administrative data

Endpoint:
in vitro cytogenicity / chromosome aberration study in mammalian cells
Remarks:
Type of genotoxicity: chromosome aberration
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)

Data source

Reference
Title:
No information
Author:
Anonymous
Year:
2013
Bibliographic source:
OECD Toolbox v3.1 (2013)

Materials and methods

Test guideline
Guideline:
OECD Guideline 473 (In Vitro Mammalian Chromosome Aberration Test)
GLP compliance:
not specified
Type of assay:
in vitro mammalian chromosome aberration test

Test material

Constituent 1
Chemical structure
Reference substance name:
Aluminium tris(2,4-pentanedionato-O,O')
EC Number:
237-741-6
EC Name:
Aluminium tris(2,4-pentanedionato-O,O')
Cas Number:
13963-57-0
Molecular formula:
C15H21AlO6
IUPAC Name:
aluminum tris(4-oxopent-2-en-2-olate)

Method

Species / strain
Species / strain / cell type:
Chinese hamster lung fibroblasts (V79)
Metabolic activation:
with and without
Metabolic activation system:
S9

Results and discussion

Test results
Species / strain:
Chinese hamster lung fibroblasts (V79)
Metabolic activation:
with and without
Genotoxicity:
negative
Remarks:
85.7% negative
Cytotoxicity / choice of top concentrations:
not specified

Applicant's summary and conclusion

Categories Display