Registration Dossier
Registration Dossier
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EC number: 237-741-6 | CAS number: 13963-57-0
Endpoint summary
Administrative data
Key value for chemical safety assessment
Effects on fertility
Link to relevant study records
- Endpoint:
- toxicity to reproduction
- Remarks:
- other: fertility
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Guideline:
- other: read across (grouping according to proteinbinding by OASIS)
- GLP compliance:
- not specified
- Species:
- rat
- Sex:
- male/female
- Route of administration:
- oral: unspecified
- Duration of treatment / exposure:
- 45d
- Dose descriptor:
- LOEL
- Effect level:
- 5.26 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Sex:
- male/female
- Reproductive effects observed:
- not specified
Reference
Effect on fertility: via oral route
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LOAEL
- 5.26 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Effect on fertility: via inhalation route
- Endpoint conclusion:
- no study available
Effect on fertility: via dermal route
- Endpoint conclusion:
- no study available
Additional information
The results for fertility toxicity in an OECD Toolbox study was LOEL (rat,oral, 45d) 5.26 mg/kg bw/day
The results for developmental tox/teratogenecity in an OECD Toolbox study was LOEL (rat,oral, 45d) 21.9 mg/kg bw/day
Effects on developmental toxicity
Link to relevant study records
- Endpoint:
- developmental toxicity
- Type of information:
- migrated information: read-across based on grouping of substances (category approach)
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Guideline:
- other: read across (grouping according to proteinbinding by OASIS)
- GLP compliance:
- not specified
- Species:
- rat
- Route of administration:
- oral: unspecified
- Duration of test:
- 45d
- Dose descriptor:
- LOEL
- Effect level:
- 21.9 mg/kg bw/day (nominal)
- Based on:
- test mat.
- Basis for effect level:
- other: developmental toxicity
- Abnormalities:
- not specified
- Developmental effects observed:
- not specified
Reference
Effect on developmental toxicity: via oral route
- Endpoint conclusion:
- adverse effect observed
- Dose descriptor:
- LOAEL
- 21.9 mg/kg bw/day
- Study duration:
- subchronic
- Species:
- rat
Effect on developmental toxicity: via inhalation route
- Endpoint conclusion:
- no study available
Effect on developmental toxicity: via dermal route
- Endpoint conclusion:
- no study available
Justification for classification or non-classification
Data lacking
Additional information
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
