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EC number: 940-820-4 | CAS number: -
- Life Cycle description
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- Ecotoxicological Summary
- Aquatic toxicity
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- Short-term toxicity to fish
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Acute Toxicity: dermal
Administrative data
- Endpoint:
- acute toxicity: dermal
- Remarks:
- This study was available at the time of registration and is submitted as part of an obligation to submit all relevant information on the substance. The study was not commisioned for REACH registration purposes.
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: Study was conducted by a GLP accredited laboratory using a test method eqiuivalent to OECD Testing Guideline 402.
Data source
Reference
- Reference Type:
- study report
- Title:
- Unnamed
- Year:
- 2 013
- Report date:
- 2013
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 402 (Acute Dermal Toxicity)
- Deviations:
- not specified
- GLP compliance:
- yes
- Test type:
- standard acute method
Test material
- Reference substance name:
- 1H-Imidazolium, 3-ethyl-1-methyl-, C9-14-branched alkylbenzenesulfonates
- IUPAC Name:
- 1H-Imidazolium, 3-ethyl-1-methyl-, C9-14-branched alkylbenzenesulfonates
- Reference substance name:
- EMI-DBS
- IUPAC Name:
- EMI-DBS
- Reference substance name:
- 1065642-34-3
- Cas Number:
- 1065642-34-3
- IUPAC Name:
- 1065642-34-3
- Test material form:
- semi-solid (amorphous): gel
- Remarks:
- migrated information: paste
- Details on test material:
- Name of test material (as cited in study report): 1H-imidazolium, 3-ethyl-1-methyl-, C9-14-branched alkylbenzenesulfonates
Constituent 1
Constituent 2
Constituent 3
Test animals
- Species:
- rat
- Strain:
- Wistar
- Sex:
- male/female
- Details on test animals or test system and environmental conditions:
- TEST ANIMALS
- Source: Acdemy of Militray Medical Sciences
- Weight at study initiation: 200 g
- Fasting period before study: 3 days
- Housing: SPF
- Acclimation period: 3 days
ENVIRONMENTAL CONDITIONS
- Temperature (°C): 20~25
- Humidity (%): 40%~70%
Administration / exposure
- Type of coverage:
- occlusive
- Vehicle:
- water
- Details on dermal exposure:
- TEST SITE
- % coverage: 40%
- Type of wrap if used: gauze
REMOVAL OF TEST SUBSTANCE
- Washing (if done): warm water
- Time after start of exposure: 24h
TEST MATERIAL
- Amount(s) applied (volume or weight with unit): 2500mg/kg bw
- Constant volume or concentration used: no
- For solids, paste formed: no - Duration of exposure:
- 24 h
- Doses:
- 2500 mg/kg bw
- No. of animals per sex per dose:
- 5
- Control animals:
- not required
- Details on study design:
- Duration of observation period following administration: 14 days
Frequency of observations and weighing: 0 d; 7 d; 14 d
Necropsy of survivors performed: no
Other examinations performed: clinical signs, body weight,organ weights, histopathology
Results and discussion
Effect levels
- Sex:
- male/female
- Dose descriptor:
- LD50
- Effect level:
- > 2 500 mg/kg bw
- Remarks on result:
- other: No 95% CL information was provided
- Mortality:
- No deaths were observed.
- Clinical signs:
- other: No clinical sign were observed.
Any other information on results incl. tables
Summary of results
Animal |
Dose Level |
Animal |
Weight (g, Average±SD) |
Death |
Mortality |
LD50 |
||
Sex |
(mg/kg bw) |
Number |
0 day |
7 days |
14 days |
Number |
% |
(g/kg bw) |
Male |
2500 |
5 |
211.4 ± 5.7 |
253.2 ± 9.7 |
288.8 ± 9.8 |
0 |
0 |
>2500 |
Female |
2500 |
5 |
213.2 ± 3.2 |
226.2 ± 4.4 |
237.2 ± 3.3 |
0 |
0 |
>2500 |
Applicant's summary and conclusion
- Interpretation of results:
- not classified
- Remarks:
- Migrated information Criteria used for interpretation of results: EU
- Conclusions:
- There were no deaths and no clinical signs were observed during the observation period. The LD50 found in the study was >2500 mg/kg bw, as such EMI-DBS is not classified as an acute dermal toxin in accordance with EU CLP criteria.
- Executive summary:
The acute dermal toxicity of the test substance was determined using a method equivalent to the OECD Guideline for Testing of Chemicals 402. A dose of 2500 mg/kg bw was applied occlusively by gauze to the skin of male and female Wistar rats. The rats were exposed to the test substance for 24 hours. There were no deaths and no clinical signs were observed during the observation period. The LD50 found in the study was >2500 mg/kg bw, as such EMI-DBS is not classified as an acute dermal toxin in accordance with EU CLP criteria.
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