Registration Dossier
Registration Dossier
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EC number: 204-101-2 | CAS number: 115-70-8
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data
Direct observations: clinical cases, poisoning incidents and other
Administrative data
- Endpoint:
- direct observations: clinical cases, poisoning incidents and other
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 2 (reliable with restrictions)
Data source
Reference
- Reference Type:
- publication
- Title:
- Patch testing with components of water-based metalworking fluids.
- Author:
- Greier, J. et al.
- Year:
- 2 003
- Bibliographic source:
- Contact Dermatitis 49, 85-90.
Materials and methods
- Study type:
- clinical case study
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 2-amino-2-ethylpropanediol
- EC Number:
- 204-101-2
- EC Name:
- 2-amino-2-ethylpropanediol
- Cas Number:
- 115-70-8
- Molecular formula:
- C5H13NO2
- IUPAC Name:
- 2-amino-2-ethylpropane-1,3-diol
Constituent 1
Method
- Type of population:
- occupational
- Subjects:
- A clinical trial of 233 patients with present or past occupational to metalworking fluids (MWF).
- Ethical approval:
- not specified
- Route of exposure:
- dermal
- Reason of exposure:
- intentional, occupational
Results and discussion
- Results of examinations:
- Only 1 patient reacted positively to AEPD.
Applicant's summary and conclusion
- Conclusions:
- Only 1 patient reacted positively to AEPD. The importance of AEPD as a MWF allergen still remains to be established.
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