Registration Dossier
Registration Dossier
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EC number: 457-320-2 | CAS number: -
Short-term toxicity to fish
Administrative data
Link to relevant study record(s)
Description of key information
The acute LL50 for freshwater fish is >670 mg/L (nominal loading rate).
Key value for chemical safety assessment
Fresh water fish
Fresh water fish
- Effect concentration:
- 670 mg/L
Additional information
No short-term toxicity to fish studies are available for EC# 457-320-2, but two such studies are available for the structurally and chemically similar compound EC # 434-650-5: both are 96-hour limit test studies in rainbow trout, conducted to GLP and in accordance with OECD Test Guideline 203, and both used Water Accomodated Fractions (WAFs) of the test substance due to its poor water solubility. The first study, conducted in 1998 used test material which was 67% EC# 434-650-5 and 33% refined base oil. The test material nominal loading rate of 1,000 mg/L was therefore equivalent to a nominal loading rate of EC# 434-650-5 of 670 mg/L. The second study, conducted in 2000, used test substance (EC# 434-650-5) at, after correcting for purity, a nominal loading rate of 94.8 mg/L.
No mortality or other treatment-related adverse effects were seen in either study. LL50 values were therefore, >670 mg/L and > 94.8 mg/L, respectively. Due to the absence of effects in either study, it is reasonable to conclude an overall LL50 for freshwater fish of >670 mg/L (nominal loading rate) for EC# 434-650-5. Based on its similar structure and chemistry, it is reasonable to use these data to read-across to EC# 457-320-2.
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