Registration Dossier
Registration Dossier
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EC number: 614-637-2 | CAS number: 68603-75-8
Bioaccumulation: terrestrial
Administrative data
- Endpoint:
- bioaccumulation: terrestrial
- Type of information:
- other: expert statement
- Adequacy of study:
- weight of evidence
- Reliability:
- 1 (reliable without restriction)
- Rationale for reliability incl. deficiencies:
- other: 1b Comparable to guideline study
Data source
Reference
- Reference Type:
- other: expert statment
- Title:
- No information
- Author:
- Frère F.
- Year:
- 2 010
Materials and methods
- Principles of method if other than guideline:
- The attached Toxicokinetic Assessment is meant to fulfill the requirement as defined in the REGULATION (EC) No 1907/2006 OF THE EUROPEAN PARLIAMENT AND OF THE COUNCIL of 18 December 2006 requests in Annex VIII, point 8.8.1:
"Assessment of the toxicokinetic behaviour of the substance to the extent that can be derived from therelevant available information."
Test material
- Reference substance name:
- 1-({3-[(2-hydroxypropyl)[(9E)-octadec-9-en-1-yl]amino]propyl}amino)propan-2-ol; 1-({3-[(2-hydroxypropyl)amino]propyl}(octadecyl)amino)propan-2-ol; 1-({3-[hexadecyl(2-hydroxypropyl)amino]propyl}amino)propan-2-ol
- EC Number:
- 614-637-2
- Cas Number:
- 68603-75-8
- Molecular formula:
- R-N(CH2CHOHCH3)xCH2CH2CH2N(CH2CHOHCH3)y with x+y=3 and where R = alkyl
- IUPAC Name:
- 1-({3-[(2-hydroxypropyl)[(9E)-octadec-9-en-1-yl]amino]propyl}amino)propan-2-ol; 1-({3-[(2-hydroxypropyl)amino]propyl}(octadecyl)amino)propan-2-ol; 1-({3-[hexadecyl(2-hydroxypropyl)amino]propyl}amino)propan-2-ol
Constituent 1
Results and discussion
Applicant's summary and conclusion
- Executive summary:
The relevant available data on Amines, N-tallow alkyltrimethylenedi-, propoxylated was analyzed to assess its potential toxicokinetic behaviour. The UVCB consists of different compounds. Most of the constituents are n-alkane-dipropylene triamines that are partly or fully propoxylated and contain primary, secondary or tertiary amine groups which are positively charged at in the physiological pH range. Overall the absorbance is expected to be low, while the metabolisation of amines common reactions of xenobiotic metabolism. Therefore a tendency for bioaccumulation is not expected. Metabolites will be excreted both via urine and bile (feces) depending on the size and charge of the molecules.
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