Registration Dossier

Diss Factsheets

Toxicological information

Acute Toxicity: oral

Currently viewing:

Administrative data

Endpoint:
acute toxicity: oral
Type of information:
experimental study
Adequacy of study:
key study
Study period:
From Aug. 18, 1992 to Sep. 24, 1992
Reliability:
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
other: Guideline study (OECD 401/423). No GLP study.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1992
Report date:
1992

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 401 (Acute Oral Toxicity)
Version / remarks:
year of guideline not reported
Deviations:
no
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 423 (Acute Oral toxicity - Acute Toxic Class Method)
Version / remarks:
reliability scoring based on 2001
Deviations:
no
GLP compliance:
no
Test type:
standard acute method
Limit test:
yes

Test material

Constituent 1
Chemical structure
Reference substance name:
1H-1,2,4-triazole, sodium salt
EC Number:
255-280-9
EC Name:
1H-1,2,4-triazole, sodium salt
Cas Number:
41253-21-8
Molecular formula:
C2H3N3.Na
IUPAC Name:
sodium 1,2,4-triazol-1-ide
Details on test material:
- Name of test material (as cited in study report): 1, 2 , 4 - TRIAZOLE SODIUM SALT
- Physical state: white - yellow powder
- Analytical purity: = 99%
- Lot/batch No.: 92/492
- Expiration date of the lot/batch: after 1995 (received by laboratory on June 25, 1992)
- Storage condition of test material: in dark and at room temperature

Test animals

Species:
rat
Strain:
Sprague-Dawley
Sex:
male/female
Details on test animals or test system and environmental conditions:
no

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
other: 0.5% (w/v) methylcellulose in water
Details on oral exposure:
no
Doses:
2000 mg/kg bw
No. of animals per sex per dose:
5/sex/dose
Control animals:
no
Details on study design:
no
Statistics:
no data

Results and discussion

Effect levels
Sex:
male/female
Dose descriptor:
LD50
Effect level:
< 2 000 mg/kg bw
Mortality:
9 rats in 10 died in less than 24 hours. 3 animals (2 males, 1 female) died between 6 and 7 hours after the start of the test. The following day, 6 rats (3 males, 3 females) were found dead. The only one surviving animal (female) was in a coma. No amelioration of its state was observed during the following 48 hours. The last one, moribund was sacrificed 3 days after the treatment.
Clinical signs:
other: One hour after the treatment, the spontaneous motor activity of all animals decreased. Some showed symptoms of respiratory difficulties (gasping). A few rats showed symptoms like piloerection and hollow side. The first severe signs of toxicity were observ
Gross pathology:
The necropsy carried out on all animals revealed stomach (meteorism, glandular mucosa diffusely red) and intestinal (small intestine distended and inflamed) changes.
Other findings:
no

Applicant's summary and conclusion

Conclusions:
Under the experimental conditions adopted, the oral LD50 of the substance 1,2,4-TRIAZOLE SODIUM SALT in male and female rats is smaller than 2000 mg/kg.
Executive summary:

Groups of 5 rats/sexe were exposed to 1,2,4 -triazole sodium salt by gavage at 2000 mg/kg bw, according to the OECD guideline. 1,2,4 -triazole sodium salt was dilued in 0.5%(w/v) methylcellulose in water. 9 rats in 10 died in less than 24 hours. Under the experimental conditions adopted, the oral LD50 of 1,2,4 -triazole sodium salt in male and female rats is smaller than 2000 mg/kg.