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Toxicological information

Acute Toxicity: inhalation

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Administrative data

Endpoint:
acute toxicity: inhalation
Type of information:
experimental study
Adequacy of study:
weight of evidence
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference
Reference Type:
publication
Title:
Morpholine
Author:
ILO (International Labour Office)
Year:
1972
Bibliographic source:
In: Encyclopaedia of occupational health and safety. 2nd ed. Vol. II (L-Z). Geneva, Switzerland: International Labour Office, 915-916

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 403 (Acute Inhalation Toxicity)
Deviations:
not specified
GLP compliance:
no
Test type:
standard acute method
Limit test:
no

Test material

Constituent 1
Chemical structure
Reference substance name:
Morpholine
EC Number:
203-815-1
EC Name:
Morpholine
Cas Number:
110-91-8
Molecular formula:
C4H9NO
IUPAC Name:
morpholine
Test material form:
liquid

Test animals

Species:
rat
Strain:
not specified
Sex:
not specified

Administration / exposure

Route of administration:
inhalation: vapour
Type of inhalation exposure:
not specified
Vehicle:
not specified
Analytical verification of test atmosphere concentrations:
not specified
Duration of exposure:
4 h
Concentrations:
6734 ppm ≈ 23,569 mg/m³
No. of animals per sex per dose:
6 animals
Control animals:
not specified
Details on study design:
- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight
Statistics:
No data

Results and discussion

Effect levels
Key result
Sex:
not specified
Dose descriptor:
LC0
Effect level:
24 mg/L air
Exp. duration:
4 h
Mortality:
No deaths (0/6) were noted.
Clinical signs:
other: There were signs of irritation and stained hair
Body weight:
The body weight gain during the observation period was normal.
Gross pathology:
No gross lesions were noted at necropsy.
Other findings:
In a further study also reported in this publication 6 rats have been exposed to 8497 ppm (31 mg/L) of morpholine vapour in a 8-h exposure and one animal died. The survivors gained weight normally and had no visible lesions at autopsy.

Applicant's summary and conclusion