Morpholine

Acute Toxicity: inhalation

Administrative data

Endpoint:

acute toxicity: inhalation

Type of information:

experimental study

Adequacy of study:

weight of evidence

Reliability:

2 (reliable with restrictions)

Rationale for reliability incl. deficiencies:

study well documented, meets generally accepted scientific principles, acceptable for assessment

Data source

Reference

Reference Type:

publication

Title:

Morpholine

Author:

ILO (International Labour Office)

Year:

1972

Bibliographic source:

In: Encyclopaedia of occupational health and safety. 2nd ed. Vol. II (L-Z). Geneva, Switzerland: International Labour Office, 915-916

Materials and methods

Test guideline

Qualifier:

equivalent or similar to guideline

Guideline:

OECD Guideline 403 (Acute Inhalation Toxicity)

Deviations:

not specified

GLP compliance:

no

Test type:

standard acute method

Limit test:

no

Test material

Test material information

Constituent 1

Reference substance name:

Morpholine

EC Number:

203-815-1

EC Name:

Morpholine

Cas Number:

110-91-8

Molecular formula:

C4H9NO

IUPAC Name:

morpholine

Test material form:

liquid

Test animals

Species:

rat

Strain:

not specified

Sex:

not specified

Administration / exposure

Route of administration:

inhalation: vapour

Type of inhalation exposure:

not specified

Vehicle:

not specified

Analytical verification of test atmosphere concentrations:

not specified

Duration of exposure:

4 h

Concentrations:

6734 ppm ≈ 23,569 mg/m³

No. of animals per sex per dose:

6 animals

Control animals:

not specified

Details on study design:

- Duration of observation period following administration: 14 days
- Necropsy of survivors performed: yes
- Other examinations performed: clinical signs, body weight

Statistics:

No data

Results and discussion

Effect levels

Key result

Sex:

not specified

Dose descriptor:

LC0

Effect level:

24 mg/L air

Exp. duration:

4 h

Mortality:

No deaths (0/6) were noted.

Clinical signs:

other: There were signs of irritation and stained hair

Body weight:

The body weight gain during the observation period was normal.

Gross pathology:

No gross lesions were noted at necropsy.

Other findings:

In a further study also reported in this publication 6 rats have been exposed to 8497 ppm (31 mg/L) of morpholine vapour in a 8-h exposure and one animal died. The survivors gained weight normally and had no visible lesions at autopsy.