Registration Dossier
Registration Dossier
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EC number: 204-327-1 | CAS number: 119-47-1
Sensitisation data (human)
Administrative data
- Endpoint:
- sensitisation data (humans)
- Type of information:
- experimental study
- Adequacy of study:
- supporting study
- Reliability:
- 4 (not assignable)
- Rationale for reliability incl. deficiencies:
- other: study data do not give sufficient experimental details
Data source
Reference
- Reference Type:
- publication
- Title:
- Alergens in rubber products
- Author:
- Kanto, H.; et al.
- Year:
- 1 999
- Bibliographic source:
- Toho Igakkai Zasshi, 46(3), 240-250
Materials and methods
- Type of sensitisation studied:
- skin
- Study type:
- other: patch-test with dermatitis cases
- Principles of method if other than guideline:
- other: patch-test
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
- EC Number:
- 204-327-1
- EC Name:
- 6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol
- Cas Number:
- 119-47-1
- Molecular formula:
- C23H32O2
- IUPAC Name:
- 2-tert-butyl-6-[(3-tert-butyl-2-hydroxy-5-methylphenyl)methyl]-4-methylphenol
- Details on test material:
- no data
Constituent 1
Method
- Type of population:
- not specified
- Controls:
- no data
- Route of administration:
- dermal
Results and discussion
- Results of examinations:
- 0/16 and 0/91 positive skin reactions in contact dermatitis patients
Any other information on results incl. tables
Patch-test Reading:
negative
0/16
0/91
Applicant's summary and conclusion
- Executive summary:
The test substance 6,6'-di-tert-butyl-2,2'-methylenedi-p-cresol was negative in the patch-test (Kanto 1999).
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