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Partition coefficient

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Reference
Endpoint:
partition coefficient
Type of information:
experimental study
Adequacy of study:
key study
Study period:
2012
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
study well documented, meets generally accepted scientific principles, acceptable for assessment
Qualifier:
according to guideline
Guideline:
other: OECD Guideline 105, flask method
Principles of method if other than guideline:
The partition coefficient was estimated based on the ratio of the solubilities in n-octanol and in water.
The individual solubilities were determined by the flask method based on OECD Guideline 105 and the ETAD method. The quantification was analyzed by HPLC-UV.
GLP compliance:
no
Type of method:
estimation method (solubility ratio)
Partition coefficient type:
octanol-water
Analytical method:
high-performance liquid chromatography
Key result
Type:
log Pow
Partition coefficient:
0
Temp.:
23 °C
Remarks on result:
other: no data on pH
Details on results:
The concentration of the pigment in water and in n-octanol was determined by HPLC-UV measurements:
Solubility in water: <30 µg/L
Solubility in n-octanol: <30 µg/L
No test item could be detected with a detection limit of 30 μg/L inboth solvents.

Estimation of log Pow:

Pow= c(n-octanol) / c( water)= 30.0 µg/L / 30.0 µg/L= 1

Log Pow= 0

Conclusions:
The partition coefficient of test substance was estimated to be log Pow= 0 at 23°C.

Description of key information

Estimated based on solubility ratio:


log Pow= 0 at 23°C

Key value for chemical safety assessment

Additional information

Bulk form:


The partition coefficient was estimated based on the ratio of the solubilities in n-octanol and in water.


The individual solubilities were determined by the flask method based on OECD Guideline 105 and the ETAD method. The quantification was analyzed by HPLC-UV.