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Toxicological information

Skin irritation / corrosion

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Administrative data

Endpoint:
skin irritation: in vivo
Type of information:
migrated information: read-across based on grouping of substances (category approach)
Adequacy of study:
key study
Study period:
1980
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: The study is well documented and performed similar to OECD 404 guideline.

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1980
Report date:
1980

Materials and methods

Test guideline
Qualifier:
equivalent or similar to guideline
Guideline:
OECD Guideline 404 (Acute Dermal Irritation / Corrosion)
Deviations:
yes
Remarks:
24 h exposure under occlusive conditions
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
Monoammonium phosphate
IUPAC Name:
Monoammonium phosphate
Constituent 2
Reference substance name:
Härter 26 Pulver
IUPAC Name:
Härter 26 Pulver
Constituent 3
Reference substance name:
Ammonium dihydrogenorthophosphate
EC Number:
231-764-5
EC Name:
Ammonium dihydrogenorthophosphate
Cas Number:
7722-76-1
IUPAC Name:
ammonium dihydrogen phosphate
Test material form:
solid: crystalline

Test animals

Species:
rabbit
Strain:
Vienna White
Details on test animals or test system and environmental conditions:
TEST ANIMALS

- Weight at study initiation: females: 3.54 kg, males: 2.95


Test system

Type of coverage:
occlusive
Preparation of test site:
shaved
Vehicle:
water
Controls:
no
Amount / concentration applied:
0.5 g of 80 % aqueous solution
Duration of treatment / exposure:
24 hours
Observation period:
9 days
Number of animals:
3 male and 3 female

Results and discussion

In vivo

Resultsopen allclose all
Irritation parameter:
erythema score
Basis:
mean
Time point:
other: 24, 72 hours
Score:
0.25
Max. score:
1
Reversibility:
fully reversible within: 72 hours
Irritation parameter:
edema score
Basis:
mean
Time point:
other: 24, 72 hours
Score:
0
Max. score:
0

Any other information on results incl. tables

time

animal 1

animal 2

animal 3

animal 4

animal 5

animal 6

erythema

24 h

1

1

0

0

0

1

72 h

0

0

0

0

0

0

9 d

0

0

0

0

0

0

edema

24 h

0

0

0

0

0

0

72 h

0

0

0

0

0

0

9 d

0

0

0

0

0

0

Applicant's summary and conclusion

Interpretation of results:
not irritating
Remarks:
Migrated information Criteria used for interpretation of results: OECD GHS
Conclusions:
Monoammonium phosphate was slightly irritant to the rabbits skin in an in vivo study according to the methods of Draize.
According to the CLP-criteria no classification is justified.