Registration Dossier
Registration Dossier
Use of this information is subject to copyright laws and may require the permission of the owner of the information, as described in the ECHA Legal Notice.
EC number: 201-152-2 | CAS number: 78-87-5
Repeated dose toxicity: oral
Administrative data
- Endpoint:
- short-term repeated dose toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- publication
- Title:
- Unnamed
- Year:
- 2 003
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- other: standard NTP methodology
- GLP compliance:
- yes
Test material
- Reference substance name:
- 1,2-dichloropropane
- EC Number:
- 201-152-2
- EC Name:
- 1,2-dichloropropane
- Cas Number:
- 78-87-5
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,2-dichloropropane
- Details on test material:
- Name. 1,2-dichloropropane
Constituent 1
Test animals
- Species:
- rat
- Strain:
- Fischer 344
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- 14 days
- Frequency of treatment:
- Consecutive days
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 125, 250, 500, 1000 or 2000 mg/kg bw/d
Basis:
- No. of animals per sex per dose:
- Groups of 5 male and 5 female
- Control animals:
- yes, concurrent vehicle
Results and discussion
Effect levels
open allclose all
- Key result
- Dose descriptor:
- NOAEL
- Effect level:
- 500 mg/kg bw/day (nominal)
- Sex:
- male/female
- Basis for effect level:
- mortality
- Key result
- Dose descriptor:
- LOAEL
- Effect level:
- 1 000 mg/kg bw/day (nominal)
- Sex:
- male/female
- Basis for effect level:
- mortality
Target system / organ toxicity
- Critical effects observed:
- not specified
Any other information on results incl. tables
GC analysis of the dosing solutions demonstrated that the achieved concentration was 95 - 100% of target. All rats given 2000 mg/kg bw died during the study, along with a single male from the 125 mg/kg bw/d group. Final mean body weight was decreased 14-15% in animals given 1000 mg/kg bw/d relative to the controls. The renal medullae were red in 4/5 males and 5/5 females given 2000 mg/kg bw/d but not in rats from the lower treatment groups.
Applicant's summary and conclusion
- Conclusions:
- Under the conditions of the study, the sub-acute NOEL for PDC in male and female rats was 500 mg/kg bw/d.
Information on Registered Substances comes from registration dossiers which have been assigned a registration number. The assignment of a registration number does however not guarantee that the information in the dossier is correct or that the dossier is compliant with Regulation (EC) No 1907/2006 (the REACH Regulation). This information has not been reviewed or verified by the Agency or any other authority. The content is subject to change without prior notice.
Reproduction or further distribution of this information may be subject to copyright protection. Use of the information without obtaining the permission from the owner(s) of the respective information might violate the rights of the owner.
