Registration Dossier
Registration Dossier
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EC number: 201-152-2 | CAS number: 78-87-5
Genetic toxicity: in vivo
Administrative data
- Endpoint:
- in vivo mammalian somatic cell study: cytogenicity / erythrocyte micronucleus
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Study period:
- 2003
- Reliability:
- 1 (reliable without restriction)
Data source
Reference
- Reference Type:
- publication
- Title:
- OECD SIDS 1,2-DICHLOROPROPANE
- Author:
- OECD SIDS
- Year:
- 2 003
- Bibliographic source:
- UNEP PUBLICATIONS
- Report date:
- 2003
Materials and methods
Test guideline
- Qualifier:
- according to guideline
- Guideline:
- EPA OPPTS 870.5395 (In Vivo Mammalian Cytogenetics Tests: Erythrocyte Micronucleus Assay)
- GLP compliance:
- yes
- Type of assay:
- micronucleus assay
Test material
- Reference substance name:
- 1,2-dichloropropane
- EC Number:
- 201-152-2
- EC Name:
- 1,2-dichloropropane
- Cas Number:
- 78-87-5
- Molecular formula:
- C3H6Cl2
- IUPAC Name:
- 1,2-dichloropropane
- Details on test material:
- Name. 1,2-dichloropropane
Constituent 1
Test animals
- Species:
- mouse
- Strain:
- CD-1
- Sex:
- male
Administration / exposure
- Route of administration:
- oral: gavage
- Duration of treatment / exposure:
- 48 hr
Doses / concentrations
- Remarks:
- Doses / Concentrations:
0, 150, 300 or 600 mg/kg bwt/d
Basis:
Results and discussion
Any other information on results incl. tables
All animals survived until the end of the observation period. Incoordination was observed in one mouse from the high-dose group. A uniform drop in body temperature (approx. 2ºC) occurred 2 hrs post-dosing in the high-dose animals. There was no statistically significant increase in the frequencies of MN-PCE in groups treated with PDC when compared to the negative controls. In contrast, a significant increase in the frequency of MN-PCE was recorded in the positive control group. The mean proportion of PCE among bone marrow erythrocytes (200/animal) was unaffected by exposure to the test material while the positive control treatment significantly reduced this value.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information): negative
1,2 dichloropropane was negative for the induction of micronuclei in this test system under the experimental conditions used.
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