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Ecotoxicological information

Short-term toxicity to aquatic invertebrates

Administrative data

Endpoint:
short-term toxicity to aquatic invertebrates
Type of information:
experimental study
Adequacy of study:
key study
Reliability:
1 (reliable without restriction)

Data source

Reference
Reference Type:
study report
Title:
Unnamed
Year:
1998

Materials and methods

Test guidelineopen allclose all
Qualifier:
according to guideline
Guideline:
OECD Guideline 202 (Daphnia sp. Acute Immobilisation Test)
Qualifier:
according to guideline
Guideline:
EU Method C.2 (Acute Toxicity for Daphnia)
GLP compliance:
yes (incl. QA statement)

Test material

Constituent 1
Chemical structure
Reference substance name:
Ethyl 2-bromo-2-methylpropionate
EC Number:
209-980-6
EC Name:
Ethyl 2-bromo-2-methylpropionate
Cas Number:
600-00-0
Molecular formula:
C6H11BrO2
IUPAC Name:
ethyl 2-bromo-2-methylpropionate

Sampling and analysis

Analytical monitoring:
yes

Test organisms

Test organisms (species):
Daphnia magna

Study design

Test type:
static
Water media type:
freshwater
Limit test:
no
Total exposure duration:
48 h

Test conditions

Hardness:
Standard dilution water (according to ISO 6341)
Test temperature:
Beetween 19.5 and 20 °C
pH:
Start : 7.78
End : 7.31 - 8.12
Dissolved oxygen:
8.3 - 9.0 mg/L
Salinity:
Not stated
Nominal and measured concentrations:
The ratio final/initial concentrations of Ethyl 2-bromoisobutyrate has been measured. The average of final concentration of Ethyl 2-bromoisobutyrate was within the designated limit of 80% of the average of initial concentrations.
Reference substance (positive control):
no

Results and discussion

Effect concentrationsopen allclose all
Duration:
24 h
Dose descriptor:
LC50
Effect conc.:
87 mg/L
Nominal / measured:
meas. (geom. mean)
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: Confident interval 95% not determinated
Duration:
48 h
Dose descriptor:
LC50
Effect conc.:
55 mg/L
Nominal / measured:
meas. (geom. mean)
Conc. based on:
test mat.
Basis for effect:
mobility
Remarks on result:
other: Range from 43 to 69 mg/L (with confident interval 95%)

Applicant's summary and conclusion

Validity criteria fulfilled:
yes
Conclusions:
The EC50-48h of ethyl 2-bromoisobutyrate on daphnia was calculated to be 87 mg/L with 95% confident ranging from 43 to 69 mg/L.
Thus, ethyl 2-bromoisobutyrate has to be considered as Harmful to aquatic life (aquatic acute toxicity 3)