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EC number: 202-811-7 | CAS number: 100-02-7
- Life Cycle description
- Uses advised against
- Endpoint summary
- Appearance / physical state / colour
- Melting point / freezing point
- Boiling point
- Density
- Particle size distribution (Granulometry)
- Vapour pressure
- Partition coefficient
- Water solubility
- Solubility in organic solvents / fat solubility
- Surface tension
- Flash point
- Auto flammability
- Flammability
- Explosiveness
- Oxidising properties
- Oxidation reduction potential
- Stability in organic solvents and identity of relevant degradation products
- Storage stability and reactivity towards container material
- Stability: thermal, sunlight, metals
- pH
- Dissociation constant
- Viscosity
- Additional physico-chemical information
- Additional physico-chemical properties of nanomaterials
- Nanomaterial agglomeration / aggregation
- Nanomaterial crystalline phase
- Nanomaterial crystallite and grain size
- Nanomaterial aspect ratio / shape
- Nanomaterial specific surface area
- Nanomaterial Zeta potential
- Nanomaterial surface chemistry
- Nanomaterial dustiness
- Nanomaterial porosity
- Nanomaterial pour density
- Nanomaterial photocatalytic activity
- Nanomaterial radical formation potential
- Nanomaterial catalytic activity
- Endpoint summary
- Stability
- Biodegradation
- Bioaccumulation
- Transport and distribution
- Environmental data
- Additional information on environmental fate and behaviour
- Ecotoxicological Summary
- Aquatic toxicity
- Endpoint summary
- Short-term toxicity to fish
- Long-term toxicity to fish
- Short-term toxicity to aquatic invertebrates
- Long-term toxicity to aquatic invertebrates
- Toxicity to aquatic algae and cyanobacteria
- Toxicity to aquatic plants other than algae
- Toxicity to microorganisms
- Endocrine disrupter testing in aquatic vertebrates – in vivo
- Toxicity to other aquatic organisms
- Sediment toxicity
- Terrestrial toxicity
- Biological effects monitoring
- Biotransformation and kinetics
- Additional ecotoxological information
- Toxicological Summary
- Toxicokinetics, metabolism and distribution
- Acute Toxicity
- Irritation / corrosion
- Sensitisation
- Repeated dose toxicity
- Genetic toxicity
- Carcinogenicity
- Toxicity to reproduction
- Specific investigations
- Exposure related observations in humans
- Toxic effects on livestock and pets
- Additional toxicological data

Eye irritation
Administrative data
- Endpoint:
- eye irritation: in vivo
- Type of information:
- experimental study
- Adequacy of study:
- weight of evidence
- Study period:
- 2000
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: Peer reviewed data collection from international group of experts.
Cross-referenceopen allclose all
- Reason / purpose for cross-reference:
- reference to same study
- Reason / purpose for cross-reference:
- reference to other study
Data source
Reference
- Reference Type:
- review article or handbook
- Title:
- Concise International Chemical Assessment Document 20; Mononitrophenols; 8.2 Irritation and sensitization
- Author:
- Fraunhofer Institute for Toxicology and Aerosol Research
- Year:
- 2 000
- Bibliographic source:
- International Programme on Chemical Safety (IPCS), ISBN 92 4 153020 0
Materials and methods
Test guidelineopen allclose all
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 405 (Acute Eye Irritation / Corrosion)
- Deviations:
- not applicable
- Qualifier:
- according to guideline
- Guideline:
- other: US Food and Drug Administration (FDA) guideline
- Deviations:
- not applicable
- GLP compliance:
- not specified
Test material
- Reference substance name:
- 4-nitrophenol
- EC Number:
- 202-811-7
- EC Name:
- 4-nitrophenol
- Cas Number:
- 100-02-7
- Molecular formula:
- C6H5NO3
- IUPAC Name:
- 4-nitrophenol
- Details on test material:
- - Name of test material (as cited in study report): 4-nitrophenol
Constituent 1
Test animals / tissue source
- Species:
- other: not stated in CICAD
- Strain:
- not specified
Test system
- Vehicle:
- unchanged (no vehicle)
- Remarks:
- in two of the studies and as 10% solution in the third study
- Controls:
- not specified
- Amount / concentration applied:
- TEST MATERIAL
- Amount(s) applied: The amount of 4-nitrophenol applied to the animals eye is not stated in CICAD
- Concentration (if solution): In the third study, a 10% solution of 4-nitrophenol was applied. The other two studies were performed with non-dissolved material. - Duration of treatment / exposure:
- Not applicable; No information on the duration of treatment is given in CICAD.
- Observation period (in vivo):
- Not applicable; No information on the observation period is given in CICAD.
- Number of animals or in vitro replicates:
- Not applicable; No information on the number of animals tested is given in CICAD.
Results and discussion
In vivo
Results
- Irritation parameter:
- overall irritation score
- Basis:
- mean
- Time point:
- other: not applicable
- Score:
- 1 - 2
- Max. score:
- 4
- Reversibility:
- not specified
- Remarks on result:
- other: study performed comparable to OECD 405
- Irritant / corrosive response data:
- Non-dissolved 4-nitrophenol was strongly irritating in a study performed according to FDA guideline, but was stated to be slightly irritating (score 1-2 of 4) in another investigation performed comparable to OECD 405.
4-nitrophenol applied as a 10% solution to the eyes was slightly irritating (FDA guideline). - Other effects:
- Not applicable.
Any other information on results incl. tables
No other information.
Applicant's summary and conclusion
- Interpretation of results:
- slightly irritating
- Remarks:
- Migrated information in two of the studies and strongly irritating in the third study. Criteria used for interpretation of results: EU
- Conclusions:
- 4-nitrophenol is cited to be slightly irritating in two of the studies (applied as non-dissolved material and as a 10% solution) and strongly irritating to the eyes in a third study (performed with non-dissolved material).
- Executive summary:
In the Concise Chemical Assessment Document on Mononitrophenols, toxicity data on 4 -nitrophenol are reviewed and summarized. Three studies on eye irritation are cited in the report showing slight irritation in two of the studies after application of a 10% solution or non-dissolved material and strong irritation in a third study where non-dissolved material was used.
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