Registration Dossier

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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Administrative data

Description of key information

Key value for chemical safety assessment

Skin sensitisation

Endpoint conclusion
Endpoint conclusion:
adverse effect observed (sensitising)
Additional information:

In the IPCS CICAD Document it is cited that in a guinea-pig maximisation test comparable to OECD 406, skin sensitization was observed in 5 out of 20 animals.

In the BUA report, an OECD sensitization test in guinea pigs on 4 -nitrophenol is reviewed. The test was performed according to the method of Magnusson & Kligman and results revealed that 4 -nitrophenol had a mildly sensitizing effect. According to the study report, 25% of the animals tested showed a positive reaction.

Based on the results of these studies it can not be excluded that 4 -nitrophenol has skin sensitizing effects.


Migrated from Short description of key information:
In the IPCS CICAD Document it is cited that in a guinea-pig maximisation test comparable to OECD 406, skin sensitization was observed in 5 out of 20 animals.
In the BUA report, an OECD sensitization test in guinea pigs on 4 -nitrophenol is reviewed. The test was performed according to the method of Magnusson & Kligman and results revealed that 4 -nitrophenol had a mildly sensitizing effect. According to the study report, 25% of the animals tested showed a positive reaction.

Respiratory sensitisation

Endpoint conclusion
Additional information:

Based on the results of the studies and taking into account the provisions laid down in Council Directive 67/548/EEC and CLP (1272/2008/EC), a skin sensitizing effect of PNF cannot be excluded.

Justification for classification or non-classification