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Registration Dossier
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EC number: 202-811-7 | CAS number: 100-02-7
Endpoint summary
Administrative data
Description of key information
Key value for chemical safety assessment
Skin sensitisation
Endpoint conclusion
- Endpoint conclusion:
- adverse effect observed (sensitising)
- Additional information:
In the IPCS CICAD Document it is cited that in a guinea-pig maximisation test comparable to OECD 406, skin sensitization was observed in 5 out of 20 animals.
In the BUA report, an OECD sensitization test in guinea pigs on 4 -nitrophenol is reviewed. The test was performed according to the method of Magnusson & Kligman and results revealed that 4 -nitrophenol had a mildly sensitizing effect. According to the study report, 25% of the animals tested showed a positive reaction.
Based on the results of these studies it can not be excluded that 4 -nitrophenol has skin sensitizing effects.
Migrated from Short description of key information:
In the IPCS CICAD Document it is cited that in a guinea-pig maximisation test comparable to OECD 406, skin sensitization was observed in 5 out of 20 animals.
In the BUA report, an OECD sensitization test in guinea pigs on 4 -nitrophenol is reviewed. The test was performed according to the method of Magnusson & Kligman and results revealed that 4 -nitrophenol had a mildly sensitizing effect. According to the study report, 25% of the animals tested showed a positive reaction.
Respiratory sensitisation
Endpoint conclusion
- Additional information:
Based on the results of the studies and taking into account the provisions laid down in Council Directive 67/548/EEC and CLP (1272/2008/EC), a skin sensitizing effect of PNF cannot be excluded.
Justification for classification or non-classification
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