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Please be aware that this old REACH registration data factsheet is no longer maintained; it remains frozen as of 19th May 2023.

The new ECHA CHEM database has been released by ECHA, and it now contains all REACH registration data. There are more details on the transition of ECHA's published data to ECHA CHEM here.

Diss Factsheets

Toxicological information

Basic toxicokinetics

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Administrative data

Endpoint:
basic toxicokinetics in vivo
Type of information:
migrated information: read-across from supporting substance (structural analogue or surrogate)
Adequacy of study:
key study
Reliability:
2 (reliable with restrictions)
Rationale for reliability incl. deficiencies:
other: Well-documented publication which meets basic scientific principles.

Data source

Reference
Reference Type:
publication
Title:
The Excretion and Metabolism of Triethylene Glycol
Author:
McKennis, H. et al.
Year:
1961
Bibliographic source:
International Journal of Toxicology 25 (2), 121 - 138

Materials and methods

Objective of study:
excretion
Principles of method if other than guideline:
Administration of C14-triethyleneglycol to the rat.
GLP compliance:
no

Test material

Constituent 1
Reference substance name:
2,2'-(ethylenedioxy)diethanol
EC Number:
203-953-2
EC Name:
2,2'-(ethylenedioxy)diethanol
Cas Number:
112-27-6
IUPAC Name:
2,2'-[ethane-1,2-diylbis(oxy)]diethanol
Details on test material:
- Name of test material (as cited in study report): triethylene glycol
- Analytical purity: 99.9%
- Locations of the label (if radiolabelling): randomly labeled 14C-triethylene glycol
- Specific activity (if radiolabelling): 5.13 µc/mg
Radiolabelling:
yes

Test animals

Species:
rat
Strain:
other: albino
Sex:
male
Details on test animals or test system and environmental conditions:
TEST ANIMALS
- Source: Albimno Farms, Red Bank, New Jersey, USA
- Metabolism cages: yes
- Diet: ad libitum; during study no food was allowed
- Water: ad libitum

Administration / exposure

Route of administration:
oral: gavage
Vehicle:
water
Doses / concentrations
Remarks:
Doses / Concentrations:
125, 140, 250 and 600 mg/kg bw
No. of animals per sex per dose / concentration:
2
Control animals:
yes

Results and discussion

Main ADME resultsopen allclose all
Type:
other: excretion (24 h)
Results:
66% of dose recovered in urine chloroform extracts (125 mg/kg bw group)
Type:
other: excretion (24 h)
Results:
65% of dose recovered in urine chloroform extracts (140 mg/kg bw group)
Type:
other: excretion (24 h)
Results:
38% of dose recovered in urine chloroform extracts (250 mg/kg bw group)
Type:
other: excretion (24 h)
Results:
56% of dose recovered in urine chloroform extracts as hydroxyacid (250 mg/kg bw group)
Type:
other: excretion (24 h)
Results:
27% of dose recovered in urine chloroform extracts (600 mg/kg bw group)
Type:
other: excretion (24 h)
Results:
40% of dose recovered in urine chloroform extracts as hydroxyacid (600 mg/kg bw group)
Type:
other: excretion (5 days)
Results:
91-98% of dose recovered (14C elimination)

Toxicokinetic / pharmacokinetic studies

Details on excretion:
Following administration of 14C-triethyleneglycol to the rat, 86-94% of the radioactivity was recovered in the urine in the subsequent 5-day period. The total excretion by way of the urine and faeces amounted to 94-97%. The expired air over a 60-h period contained approximately 1% of the administered dose.

Metabolite characterisation studies

Details on metabolites:
The chromatograms of chloroform extracts of urine showed no evidence of ethylene glycol or diethyleneglycol.
One oxidation product is suggested to be a monocarboxylic acid which arises by metabolic oxidation of a single terminal hydroxyl group of the parent glycol.

Applicant's summary and conclusion

Conclusions:
Interpretation of results (migrated information): no bioaccumulation potential based on study results
High degree of elimination of triethyleneglycol and its metabolites via the urine