Registration Dossier
Registration Dossier
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EC number: 201-939-0 | CAS number: 89-78-1
Acute Toxicity: oral
Administrative data
- Endpoint:
- acute toxicity: oral
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: sufficient documented for evaluation
Data source
Reference
- Reference Type:
- publication
- Title:
- Food flavourings and compounds of related structure I. Acute oral toxicity
- Author:
- Jenner PM, Hagan EC, Taylor JM, Cook EL, Fitzhugh OG
- Year:
- 1 964
- Bibliographic source:
- Fd. Cosmet. Toxicol. 2, 327-343
Materials and methods
- Principles of method if other than guideline:
- Groups of 10 young adult Osborne-Medel rats were given menthol by intubation. Animals were observed for 2 weeks during which time the development of toxic signs were followed and time of death noted. The acute oral LD50 was determined.
- GLP compliance:
- no
- Test type:
- standard acute method
Test material
- Reference substance name:
- Menthol
- EC Number:
- 201-939-0
- EC Name:
- Menthol
- Cas Number:
- 89-78-1
- Molecular formula:
- C10H20O
- IUPAC Name:
- 2-isopropyl-5-methylcyclohexanol
Constituent 1
- Specific details on test material used for the study:
- OTHER SPECIFICS: Menthol (p-menthan-3-ol)
Test animals
- Species:
- rat
- Strain:
- Osborne-Mendel
- Sex:
- male/female
Administration / exposure
- Route of administration:
- oral: gavage
- Vehicle:
- corn oil
- Doses:
- no data
- No. of animals per sex per dose:
- 5 males + 5 females/group
- Control animals:
- not specified
Results and discussion
Effect levels
- Key result
- Dose descriptor:
- LD50
- Effect level:
- 3 180 mg/kg bw
Any other information on results incl. tables
toxic signs: ataxia, scrawny appearance
death time: 4 hr - 3 days
Applicant's summary and conclusion
- Interpretation of results:
- GHS criteria not met
- Conclusions:
- The acute oral LD50 was 3180 mg/kg bw (rat, male/female)
- Executive summary:
Groups of 10 young adult Osborne-Medel rats were given menthol by intubation. Animals were observed for 2 weeks during which time the development of toxic signs were followed and time of death noted.
The acute oral LD50 was 3180 mg/kg bw (rat, male/female)
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