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EC number: 233-141-3 | CAS number: 10043-67-1
Genetic toxicity: in vitro
Administrative data
- Endpoint:
- in vitro cytogenicity / chromosome aberration study in mammalian cells
- Remarks:
- Type of genotoxicity: chromosome aberration
- Type of information:
- experimental study
- Adequacy of study:
- key study
- Reliability:
- 2 (reliable with restrictions)
- Rationale for reliability incl. deficiencies:
- other: well documented peer-reviewed publication
Data source
Reference
- Reference Type:
- publication
- Title:
- A comparative analysis of data on the clastogenicity of 951 chemical substances tested in mammalian cell cultures
- Author:
- M. Ishidate Jr., M.C. Harnois and T. Sofuni
- Year:
- 1 988
- Bibliographic source:
- Mutation Research, 195 (1988) 151-213
Materials and methods
Test guideline
- Qualifier:
- equivalent or similar to guideline
- Guideline:
- OECD Guideline 473 (In Vitro Mammalian Chromosome Aberration Test)
- Deviations:
- not specified
- GLP compliance:
- not specified
- Type of assay:
- in vitro mammalian chromosome aberration test
Test material
- Reference substance name:
- Aluminium potassium sulfate
- IUPAC Name:
- Aluminium potassium sulfate
- Reference substance name:
- Aluminium potassium bis(sulphate)
- EC Number:
- 233-141-3
- EC Name:
- Aluminium potassium bis(sulphate)
- Cas Number:
- 10043-67-1
- Molecular formula:
- Al.2H2O4S.K
- IUPAC Name:
- aluminium potassium bis(sulphate)
Constituent 1
Constituent 2
Method
- Target gene:
- A clonal sub-line of fibroblasts derivedfrom lung tissue (Koyama et al., 1970)
Species / strain
- Species / strain / cell type:
- Chinese hamster lung fibroblasts (V79)
- Details on mammalian cell type (if applicable):
- A clonal sub-line of fibroblasts derivedfrom lung tissue (Koyama et al., 1970)
- Additional strain / cell type characteristics:
- not specified
- Metabolic activation:
- without
- Test concentrations with justification for top dose:
- 1000 µg/ml = 3.9 mmol/L Aluminium potassium sulfate
Controls
- Untreated negative controls:
- not specified
- Negative solvent / vehicle controls:
- not specified
- True negative controls:
- not specified
- Positive controls:
- not specified
- Positive control substance:
- not specified
Results and discussion
Test results
- Species / strain:
- Chinese hamster lung fibroblasts (V79)
- Metabolic activation:
- without
- Genotoxicity:
- negative
- Cytotoxicity / choice of top concentrations:
- not specified
- Vehicle controls validity:
- not specified
- Untreated negative controls validity:
- not specified
- Positive controls validity:
- not specified
- Remarks on result:
- other: all strains/cell types tested
- Remarks:
- Migrated from field 'Test system'.
Applicant's summary and conclusion
- Conclusions:
- Interpretation of results (migrated information):negative without metabolic activationNOEL-48h for in vitro Mammalian Chromosome Aberration Test at Chinese hamster lung fibroblasts (V79 = 3.9 mmol/L = 1006 mg/Lfor aluminium potassium sulfate. Result: negative without metabolic activation.
- Executive summary:
NOEL-48h for in vitro Mammalian Chromosome Aberration Test
at Chinese hamster lung fibroblasts (V79 = 3.9 mmol/L = 1006 mg/L for aluminium potassium sulfate.
Result: negative without metabolic activation.
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