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Physical & Chemical properties

Boiling point

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boiling point
Type of information:
experimental study
Adequacy of study:
key study
Study period:
report date: 2010-01-06
1 (reliable without restriction)
Rationale for reliability incl. deficiencies:
comparable to guideline study
according to guideline
OECD Guideline 103 (Boiling point/boiling range)
according to guideline
EU Method A.2 (Boiling Temperature)
GLP compliance:
Type of method:
differential scanning calorimetry
Key result
Boiling pt.:
290.5 °C
Atm. press.:
1 013 hPa

Atmospheric pressure during the assay has not been measured; the boiling temperature was given without any correction.

Result of the boiling point:


Test item

Reference item


Assay 1

Assay 2

Mean(+/- Standard deviation)



Weight (mg)






Boiling point (°C)



290.5 +/- 1.0


249.0 - 250.5

According to the results of the reference item, the test has to be considered as valid.

The boiling point of 4-TBC is 290.5°C +/- 0.1°C.
Executive summary:

In a study (Processium, 2010), the boiling point of 4-tert-butylpyrocatechol was assessed using the differential scanning calorimetry, according to the regulation (EC) n°440/2008, A.2, and to the OECD Guideline n°103.


A test item amount of 5 mg was heated up from 30 to 300°C with a rate of 10°C/min. During the experiment, two samples were measured. The quantities of heat absorbed or released were measured by Differential Scanning Calorimetry and recorded. A reference sample (around 5 mg) of benzoic acid was measured in order to evaluate the experimental procedure.

The results of the boiling point of 4 -TBC were: 289.8°C and 291.2°C and of the reference item: 249.7°C.

According to the results of the reference item, the test has to be considered as valid.

In conclusion, the boiling point of 4 -tert-butylpyrocatechol is 290.5°C +/- 1.0°C.

This study is classified as acceptable and satisfies the guideline requirements for a boiling point study.

Description of key information

Boiling point: 290.5°C +/- 0.1°C

Key value for chemical safety assessment

Boiling point at 101 325 Pa:
290.5 °C

Additional information

One experimental study (Processium, 2010) with reliability 1 according to Klimisch was available and was selected as key study. Boiling point was determined according to the regulation (EC) n°440/2008, A.2.

Data coming from peer-review handbooks were available. As the values are in the same range, they are used in a supporting approach.